E2F
Gene Ontology Biological Process
- DNA endoreduplication [IGI, IMP]
- G1/S transition of mitotic cell cycle [TAS]
- antimicrobial humoral response [IMP]
- cellular process [IMP]
- dendrite morphogenesis [IMP]
- eggshell chorion gene amplification [TAS]
- growth [NAS]
- imaginal disc development [TAS]
- imaginal disc-derived wing morphogenesis [IMP]
- muscle tissue development [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- neuron development [IMP]
- nurse cell apoptotic process [TAS]
- positive regulation of cell proliferation [NAS]
- positive regulation of gene expression [IMP]
- positive regulation of nurse cell apoptotic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [TAS]
- regulation of cell cycle [IMP, NAS]
- regulation of hemocyte proliferation [IMP]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [NAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II regulatory region DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IPI]
- sequence-specific DNA binding transcription factor activity [IDA, ISS]
- transcription factor binding [IPI]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II regulatory region DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IPI]
- sequence-specific DNA binding transcription factor activity [IDA, ISS]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
- Rb-E2F complex [IDA]
- nucleus [IDA, NAS]
DP
Gene Ontology Biological Process
- dorsal/ventral axis specification, ovarian follicular epithelium [IMP]
- eggshell chorion gene amplification [TAS]
- endomitotic cell cycle [TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- mitotic cell cycle [IMP]
- nurse cell apoptotic process [TAS]
- oogenesis [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of nurse cell apoptotic process [IMP]
- regulation of cell cycle [IMP, NAS]
- regulation of transcription from RNA polymerase II promoter [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo.
Retinoblastoma protein and E2-promoter binding factor (E2F) family members are important regulators of G1-S phase progression. Deregulated E2F also sensitizes cells to apoptosis, but this aspect of E2F function is poorly understood. Studies of E2F-induced apoptosis have mostly been carried out in tissue culture cells, and the analysis of the factors that are important for this process has been restricted ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DP E2F | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 18.9865 | BioGRID | 2866743 | |
| E2F DP | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | FlyBase | - | |
| DP E2F | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | FlyBase | - | |
| E2F DP | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| E2F DP | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| E2F DP | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| DP E2F | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |