DM
Gene Ontology Biological Process
- DNA endoreduplication [IMP]
- cell competition in a multicellular organism [IMP]
- cell proliferation [IEP]
- cellular process [IMP]
- embryo development ending in birth or egg hatching [IEP]
- embryonic pattern specification [IGI]
- negative regulation of Notch signaling pathway [IGI]
- neurogenesis [IGI]
- oogenesis [TAS]
- positive regulation of cell growth [TAS]
- positive regulation of developmental growth [IMP]
- positive regulation of growth [IMP, TAS]
- positive regulation of multicellular organism growth [TAS]
- positive regulation of neurogenesis [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of apoptotic process [IMP]
- regulation of autophagy [IMP]
- regulation of cell cycle [TAS]
- regulation of cell growth [IMP]
- regulation of cell size [TAS]
- regulation of imaginal disc-derived wing size [IMP]
- regulation of organ growth [IMP]
- regulation of transcription, DNA-templated [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GRO
Gene Ontology Biological Process
- actin filament organization [IMP]
- dendrite morphogenesis [IMP]
- lateral inhibition [IMP]
- negative regulation of Wnt signaling pathway [NAS]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of smoothened signaling pathway [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IPI, TAS]
- negative regulation of transcription, DNA-templated [IDA, IGI, NAS, TAS]
- nervous system development [IMP, NAS]
- regulation of transcription, DNA-templated [IGI, IMP]
- sex determination, primary response to X:A ratio [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleus [NAS, TAS]
- protein complex [IPI]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A Myc-Groucho complex integrates EGF and Notch signaling to regulate neural development.
Integration of patterning cues via transcriptional networks to coordinate gene expression is critical during morphogenesis and misregulated in cancer. Using DNA adenine methyltransferase (Dam)ID chromatin profiling, we identified a protein-protein interaction between the Drosophila Myc oncogene and the Groucho corepressor that regulates a subset of direct dMyc targets. Most of these shared targets affect fate or mitosis particularly during neurogenesis, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GRO DM | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | FlyBase | - | |
| DM GRO | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| GRO DM | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |