SOG
Gene Ontology Biological Process
- BMP signaling pathway [NAS]
- amnioserosa formation [TAS]
- ectoderm development [NAS, TAS]
- imaginal disc-derived wing vein morphogenesis [IMP]
- maternal specification of dorsal/ventral axis, oocyte, soma encoded [IMP]
- negative regulation of transforming growth factor beta receptor signaling pathway [NAS, TAS]
- positive regulation of transforming growth factor beta receptor signaling pathway [TAS]
- posterior Malpighian tubule development [IMP]
- regulation of BMP signaling pathway [TAS]
- ring gland development [IMP]
- terminal region determination [IGI]
- torso signaling pathway [IGI]
- zygotic determination of anterior/posterior axis, embryo [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HIP14
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
dHIP14-dependent palmitoylation promotes secretion of the BMP antagonist Sog.
Analysis of diverse signaling systems has revealed that one important level of control is regulation of membrane trafficking of ligands and receptors. The activities of some ligands are also regulated by whether they are membrane bound or secreted. In Drosophila, several morphogenetic signals that play critical roles in development have been found to be subject to such regulation. For example, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HIP14 SOG | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | FlyBase | - | |
| HIP14 SOG | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |