SU(VAR)205
Gene Ontology Biological Process
- DNA hypermethylation [IMP]
- chromatin silencing [IMP]
- chromatin silencing at centromere [IMP]
- chromosome organization [IMP]
- establishment of chromatin silencing [IMP]
- gene silencing [IDA, IMP]
- heterochromatin assembly [IDA]
- histone H4-K20 trimethylation [IMP]
- negative regulation of transcription, DNA-templated [NAS]
- neurogenesis [IMP]
- positive regulation of extent of heterochromatin assembly [IMP]
- positive regulation of histone H3-K9 dimethylation [IDA, IMP]
- positive regulation of transcription, DNA-templated [TAS]
- regulation of apoptotic process [IMP]
- regulation of histone methylation [IMP]
- regulation of transcription, DNA-templated [IMP]
- telomere maintenance [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- chromosome [IDA]
- chromosome, centromeric region [NAS, TAS]
- chromosome, telomeric region [IDA]
- condensed chromosome [IDA]
- condensed nuclear chromosome, centromeric region [IDA]
- euchromatin [IDA]
- heterochromatin [IDA, NAS, TAS]
- nuclear heterochromatin [IDA]
- nucleus [IDA, NAS]
- pericentric heterochromatin [IDA]
- polytene chromosome [IDA]
- polytene chromosome band [IDA]
- polytene chromosome chromocenter [IDA, TAS]
- polytene chromosome puff [IDA, TAS]
- polytene chromosome, telomeric region [IDA, TAS]
HP5
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Heterochromatin-associated interactions of Drosophila HP1a with dADD1, HIPP1, and repetitive RNAs.
Heterochromatin protein 1 (HP1a) has conserved roles in gene silencing and heterochromatin and is also implicated in transcription, DNA replication, and repair. Here we identify chromatin-associated protein and RNA interactions of HP1a by BioTAP-XL mass spectrometry and sequencing from Drosophila S2 cells, embryos, larvae, and adults. Our results reveal an extensive list of known and novel HP1a-interacting proteins, of which ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SU(VAR)205 HP5 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| HP5 SU(VAR)205 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |