LFT
Gene Ontology Biological Process
Gene Ontology Cellular Component
FT
Gene Ontology Biological Process
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [IDA, ISS, NAS]
- cell morphogenesis involved in differentiation [IMP]
- cell proliferation [IMP]
- cell-cell adhesion mediated by cadherin [IDA]
- equator specification [IMP, NAS]
- establishment of body hair planar orientation [IMP]
- establishment of epithelial cell apical/basal polarity [IMP]
- establishment of imaginal disc-derived wing hair orientation [IMP, TAS]
- establishment of ommatidial planar polarity [IGI, IMP, TAS]
- establishment of planar polarity [IGI, IMP]
- establishment of tissue polarity [IMP, NAS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [IPI]
- hippo signaling [IGI]
- homophilic cell adhesion via plasma membrane adhesion molecules [ISS]
- imaginal disc growth [IMP]
- imaginal disc-derived wing morphogenesis [IMP]
- microtubule cytoskeleton organization involved in establishment of planar polarity [IMP]
- negative regulation of Wnt signaling pathway [TAS]
- negative regulation of cell proliferation [IMP]
- negative regulation of growth [IMP]
- negative regulation of imaginal disc growth [IMP, TAS]
- ommatidial rotation [TAS]
- peptide cross-linking [IPI]
- regulation of growth [IGI, IMP]
- regulation of organ growth [IGI]
- regulation of protein localization [IMP]
- regulation of tube length, open tracheal system [IMP]
- single organismal cell-cell adhesion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Drosophila lowfat, a novel modulator of Fat signaling.
The Fat-Hippo-Warts signaling network regulates both transcription and planar cell polarity. Despite its crucial importance to the normal control of growth and planar polarity, we have only a limited understanding of the mechanisms that regulate Fat. We report here the identification of a conserved cytoplasmic protein, Lowfat (Lft), as a modulator of Fat signaling. Drosophila Lft, and its human homologs ... [more]
Throughput
- Low Throughput