P38B
Gene Ontology Biological Process
- MAPK cascade [IDA, NAS]
- cellular response to arsenic-containing substance [IDA]
- cellular response to cadmium ion [IDA]
- cellular response to reactive oxygen species [IDA]
- defense response [NAS]
- defense response to bacterium [IMP]
- defense response to fungus [IMP]
- determination of adult lifespan [IMP]
- heart morphogenesis [IGI]
- imaginal disc-derived wing morphogenesis [IDA]
- immune response [IMP]
- paracrine signaling [IGI]
- positive regulation of cell size [IGI, IMP]
- positive regulation of multicellular organism growth [IMP]
- positive regulation of protein phosphorylation [IGI]
- protein phosphorylation [NAS]
- reactive oxygen species metabolic process [IGI]
- regulation of BMP signaling pathway [IDA]
- regulation of adult chitin-containing cuticle pigmentation [IGI]
- regulation of cellular response to oxidative stress [IMP]
- regulation of innate immune response [IDA]
- regulation of terminal button organization [IMP]
- response to bacterium [IDA]
- response to heat [IMP]
- response to hydrogen peroxide [IMP]
- response to salt stress [IGI, IMP]
- response to starvation [IMP]
- transforming growth factor beta receptor signaling pathway [IGI]
Gene Ontology Molecular Function
PTP-ER
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
High-resolution protein interaction map of the Drosophila melanogaster p38 mitogen-activated protein kinases reveals limited functional redundancy.
Functional redundancy is a pivotal mechanism that supports the robustness of biological systems at a molecular, cellular, and organismal level. The extensive prevalence of redundancy in molecular networks has been highlighted by recent systems biology studies; however, a detailed mechanistic understanding of redundant functions in specific signaling modules is often missing. We used affinity purification of protein complexes coupled to ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| P38B PTP-ER | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |