P38B
Gene Ontology Biological Process
- MAPK cascade [IDA, NAS]
- cellular response to arsenic-containing substance [IDA]
- cellular response to cadmium ion [IDA]
- cellular response to reactive oxygen species [IDA]
- defense response [NAS]
- defense response to bacterium [IMP]
- defense response to fungus [IMP]
- determination of adult lifespan [IMP]
- heart morphogenesis [IGI]
- imaginal disc-derived wing morphogenesis [IDA]
- immune response [IMP]
- paracrine signaling [IGI]
- positive regulation of cell size [IGI, IMP]
- positive regulation of multicellular organism growth [IMP]
- positive regulation of protein phosphorylation [IGI]
- protein phosphorylation [NAS]
- reactive oxygen species metabolic process [IGI]
- regulation of BMP signaling pathway [IDA]
- regulation of adult chitin-containing cuticle pigmentation [IGI]
- regulation of cellular response to oxidative stress [IMP]
- regulation of innate immune response [IDA]
- regulation of terminal button organization [IMP]
- response to bacterium [IDA]
- response to heat [IMP]
- response to hydrogen peroxide [IMP]
- response to salt stress [IGI, IMP]
- response to starvation [IMP]
- transforming growth factor beta receptor signaling pathway [IGI]
Gene Ontology Molecular Function
MAPK-AK2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
High-resolution protein interaction map of the Drosophila melanogaster p38 mitogen-activated protein kinases reveals limited functional redundancy.
Functional redundancy is a pivotal mechanism that supports the robustness of biological systems at a molecular, cellular, and organismal level. The extensive prevalence of redundancy in molecular networks has been highlighted by recent systems biology studies; however, a detailed mechanistic understanding of redundant functions in specific signaling modules is often missing. We used affinity purification of protein complexes coupled to ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MAPK-AK2 P38B | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| P38B MAPK-AK2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | FlyBase | - | |
| P38B MAPK-AK2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | FlyBase | - | |
| P38B MAPK-AK2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| MAPK-AK2 P38B | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |