SO
Gene Ontology Biological Process
- Bolwig's organ morphogenesis [IMP]
- circadian rhythm [IGI]
- compound eye development [IMP, NAS]
- compound eye morphogenesis [IMP]
- entrainment of circadian clock [IMP]
- eye-antennal disc morphogenesis [TAS]
- glial cell migration [IMP]
- optic lobe placode formation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- regulation of transcription, DNA-templated [ISS]
- ring gland development [IMP]
- spermatogenesis [IMP]
Gene Ontology Molecular Function
EYA
Gene Ontology Biological Process
- Bolwig's organ morphogenesis [IMP]
- axon guidance [IGI]
- compound eye cone cell differentiation [IMP]
- compound eye development [IMP, NAS]
- compound eye photoreceptor development [IMP]
- eye-antennal disc morphogenesis [IMP, TAS]
- gonad development [IMP, NAS]
- innate immune response [IGI]
- larval somatic muscle development [IMP]
- male gonad development [IMP]
- mesoderm development [IMP]
- negative regulation of cell fate specification [IMP]
- optic lobe placode formation [IMP]
- ovarian follicle cell development [IMP]
- photoreceptor cell axon guidance [IGI, IMP]
- pigment cell development [IMP]
- pole cell migration [TAS]
- positive regulation of gene expression [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IPI]
- protein dephosphorylation [IDA]
- response to light stimulus [IMP]
- salivary gland morphogenesis [IMP]
- spermatogenesis [IMP]
- transcription, DNA-templated [TAS]
- ventral cord development [IGI]
Gene Ontology Molecular Function
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Partner specificity is essential for proper function of the SIX-type homeodomain proteins Sine oculis and Optix during fly eye development.
The development of the Drosophila visual system utilizes two members of the highly conserved Six-Homeobox family of transcription factor, Sine oculis and Optix. Although in vitro studies have detected differences in DNA-binding and interactions with some co-factors, questions remain as to what extent the activity for these two transcriptional regulators is redundant or specific in vivo. In this work, we ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| EYA SO | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | FlyBase | - | |
| SO EYA | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | FlyBase | - | |
| EYA SO | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | FlyBase | - | |
| EYA SO | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | FlyBase | - | |
| SO EYA | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| EYA SO | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| EYA SO | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| EYA SO | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| SO EYA | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |