BLOW
Gene Ontology Biological Process
Gene Ontology Molecular Function
CRK
Gene Ontology Biological Process
- border follicle cell migration [IMP]
- ephrin receptor signaling pathway [ISS]
- imaginal disc fusion, thorax closure [IMP]
- myoblast fusion [TAS]
- phagocytosis, engulfment [IMP]
- positive regulation of JNK cascade [IDA]
- regulation of Rho GTPase activity [ISS]
- regulation of actin cytoskeleton organization [ISS]
- signal transduction [NAS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Competition between Blown fuse and WASP for WIP binding regulates the dynamics of WASP-dependent actin polymerization in vivo.
Dynamic rearrangements of the actin cytoskeleton play a key role in numerous cellular processes. In Drosophila, fusion between a muscle founder cell and a fusion competent myoblast (FCM) is mediated by an invasive, F-actin-enriched podosome-like structure (PLS). Here, we show that the dynamics of the PLS is controlled by Blown fuse (Blow), a cytoplasmic protein required for myoblast fusion but ... [more]
Throughput
- Low Throughput