Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.

Publication

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.

Chari A, Golas MM, Klingenhaeger M, Neuenkirchen N, Sander B, Englbrecht C, Sickmann A, Stark H, Fischer U

Spliceosomal small nuclear ribonucleoproteins (snRNPs) are essential components of the nuclear pre-mRNA processing machinery. A hallmark of these particles is a ring-shaped core domain generated by the binding of Sm proteins onto snRNA. PRMT5 and SMN complexes mediate the formation of the core domain in vivo. Here, we have elucidated the mechanism of this reaction by both biochemical and structural ... [more]

Cell Oct. 31, 2008; 135(3);497-509 [Pubmed: 18984161]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
SMF SME	Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.	Giot L (2003)	High	-	BioGRID	-

Curated By

FlyBase

Interaction Summary

SMF

Gene Ontology Biological Process

Gene Ontology Cellular Component

SME