FAF
Gene Ontology Biological Process
- cellularization [IMP]
- compound eye development [IMP]
- defense response to Gram-negative bacterium [IMP]
- dorsal/ventral axis specification [IGI, IMP]
- embryo development [IMP]
- endocytosis [NAS]
- germ cell migration [TAS]
- mystery cell differentiation [IMP, TAS]
- negative regulation of innate immune response [IMP]
- negative regulation of proteolysis [NAS]
- nuclear migration [IMP]
- protein deubiquitination [IDA, IMP, NAS, TAS]
- ubiquitin-dependent protein catabolic process [IGI]
Gene Ontology Molecular Function
PAR-1
Gene Ontology Biological Process
- actin filament organization [IMP]
- anterior/posterior axis specification [TAS]
- antimicrobial humoral response [IMP]
- axis specification [IMP]
- border follicle cell delamination [IMP]
- border follicle cell migration [IMP]
- establishment of imaginal disc-derived wing hair orientation [IMP]
- gamete generation [IMP]
- germarium-derived oocyte fate determination [IMP, TAS]
- maintenance of protein location [TAS]
- microtubule cytoskeleton organization [IMP]
- microtubule cytoskeleton organization involved in establishment of planar polarity [IMP]
- oocyte anterior/posterior axis specification [TAS]
- oocyte differentiation [TAS]
- oocyte microtubule cytoskeleton organization [IMP, TAS]
- oocyte nucleus localization involved in oocyte dorsal/ventral axis specification [IMP]
- ovarian follicle cell development [IMP]
- pole plasm oskar mRNA localization [TAS]
- pole plasm protein localization [IMP]
- protein phosphorylation [IDA, ISS, NAS]
- regulation of Wnt signaling pathway [TAS]
- regulation of cell shape [IMP]
- regulation of pole plasm oskar mRNA localization [IMP]
- synaptic growth at neuromuscular junction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated Aβ toxicity in Drosophila.
The conserved kinases PAR-1/MARK are critically involved in processes such as asymmetric cell division, cell polarity and neuronal differentiation. Their deregulation has been implicated in diseases including Alzheimer's disease and cancer. Given the importance of PAR-1/MARK in health and disease, their activities need to be tightly controlled. However, little is known about the molecular mechanisms underlying their regulation in vivo. ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
FAF PAR-1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | Low | - | BioGRID | - |