CAPT
Gene Ontology Biological Process
- actin filament organization [IMP]
- actin polymerization or depolymerization [IMP]
- cell morphogenesis [IMP]
- chaeta morphogenesis [IMP]
- compound eye development [IMP]
- muscle cell cellular homeostasis [IGI]
- oocyte microtubule cytoskeleton polarization [IMP]
- oogenesis [IMP]
- photoreceptor cell axon guidance [IMP]
- regulation of cell shape [IMP]
- rhabdomere development [IMP]
- wing disc dorsal/ventral pattern formation [IMP]
Gene Ontology Molecular Function
ACT42A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding.
We demonstrate that Drosophila capulet (capt), a homolog of the adenylyl cyclase-associated protein that binds and regulates actin in yeast, associates with Abl in Drosophila cells, suggesting a functional relationship in vivo. We find a robust and specific genetic interaction between capt and Abl at the midline choice point where the growth cone repellent Slit functions to restrict axon crossing. ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
ACT42A CAPT | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |