BAIT
HSPB2
27kDa, 2810021G24Rik, HSP27, MKBP
heat shock protein 2
GO Process (2)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
Mus musculus
PREY
AIFM1
AIF, AIFsh2, Hq, Pdcd8, RP23-35N5.1
apoptosis-inducing factor, mitochondrion-associated 1
GO Process (12)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- apoptotic mitochondrial changes [TAS]
- apoptotic process [ISO]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IMP]
- mitochondrial respiratory chain complex I assembly [ISO]
- neuron apoptotic process [IGI]
- neuron differentiation [ISO]
- oxidation-reduction process [ISO]
- positive regulation of apoptotic process [TAS]
- positive regulation of cell death [IMP]
- regulation of apoptotic DNA fragmentation [IGI]
- response to oxidative stress [TAS]
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome.
Small Heat Shock Proteins (sHSPs) are molecular chaperones that transiently interact with other proteins, thereby assisting with quality control of proper protein folding and/or degradation. They are also recruited to protect cells from a variety of stresses in response to extreme heat, heavy metals, and oxidative-reductive stress. Although ten human sHSPs have been identified, their likely diverse biological functions remain ... [more]
PLoS ONE Oct. 16, 2015; 10(10);e0133994 [Pubmed: 26465331]
Throughput
- High Throughput
Curated By
- BioGRID