BAIT
MDM2
1700007J15Rik, AA415488, Mdm-2
transformed mouse 3T3 cell double minute 2
GO Process (24)
GO Function (9)
GO Component (9)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [ISO]
- establishment of protein localization [ISO]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell cycle arrest [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of protein processing [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- peptidyl-lysine modification [ISO]
- positive regulation of cell cycle [IGI]
- positive regulation of gene expression [ISO]
- positive regulation of mitotic cell cycle [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein export from nucleus [ISO]
- protein catabolic process [IDA]
- protein complex assembly [ISO]
- protein destabilization [ISO]
- protein localization to nucleus [ISO]
- protein ubiquitination [IDA, ISO]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- regulation of protein catabolic process [ISO]
- traversing start control point of mitotic cell cycle [IDA]
Gene Ontology Molecular Function
Mus musculus
PREY
PTCH1
A230106A15Rik, Ptc, Ptc1, Ptch, mes
patched homolog 1
GO Process (48)
GO Function (10)
GO Component (12)
Gene Ontology Biological Process
- brain development [IMP]
- branching involved in ureteric bud morphogenesis [IMP]
- cell differentiation involved in kidney development [IGI]
- cell proliferation involved in metanephros development [IMP]
- cellular response to cholesterol [ISO]
- dorsal/ventral neural tube patterning [IMP]
- dorsal/ventral pattern formation [IGI]
- embryonic limb morphogenesis [IGI, IMP]
- embryonic organ development [IGI]
- epidermis development [IMP]
- glucose homeostasis [IMP]
- heart morphogenesis [IMP]
- hindlimb morphogenesis [IMP]
- in utero embryonic development [IGI]
- keratinocyte proliferation [IMP]
- limb morphogenesis [ISO]
- mammary gland development [IMP]
- mammary gland duct morphogenesis [IMP]
- mammary gland epithelial cell differentiation [IMP]
- negative regulation of cell division [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of multicellular organism growth [IMP]
- negative regulation of osteoblast differentiation [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of smoothened signaling pathway [IGI, IMP, NAS]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- neural plate axis specification [IMP]
- neural tube closure [IMP]
- neural tube formation [IDA]
- neural tube patterning [ISO]
- organ morphogenesis [IMP]
- pattern specification process [IMP]
- pharyngeal system development [ISO]
- positive regulation of cholesterol efflux [ISO]
- protein processing [IMP]
- protein targeting to plasma membrane [ISO]
- regulation of cell proliferation [IMP]
- regulation of growth [IMP]
- regulation of mitotic cell cycle [IMP]
- regulation of protein localization [IDA, IMP]
- regulation of smoothened signaling pathway [IGI, IMP]
- response to chlorate [IDA]
- signal transduction [IDA, TAS]
- smoothened signaling pathway [IDA, IGI]
- smoothened signaling pathway involved in dorsal/ventral neural tube patterning [IMP]
- somite development [IMP, ISO]
- spinal cord motor neuron differentiation [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- axonal growth cone [ISO]
- caveola [ISO]
- dendritic growth cone [ISO]
- extracellular region [TAS]
- integral component of plasma membrane [TAS]
- intracellular membrane-bounded organelle [ISO]
- midbody [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [ISO]
- primary cilium [IDA]
Mus musculus
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
The p53 inhibitor MDM2 facilitates Sonic Hedgehog-mediated tumorigenesis and influences cerebellar foliation.
Disruption of cerebellar granular neuronal precursor (GNP) maturation can result in defects in motor coordination and learning, or in medulloblastoma, the most common childhood brain tumor. The Sonic Hedgehog (Shh) pathway is important for GNP proliferation; however, the factors regulating the extent and timing of GNP proliferation, as well as GNP differentiation and migration are poorly understood. The p53 tumor ... [more]
PLoS ONE Mar. 18, 2011; 6(3);e17884 [Pubmed: 21437245]
Throughput
- Low Throughput
Curated By
- BioGRID