ADAP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
ARF6
Gene Ontology Biological Process
- GTP catabolic process [TAS]
- cell adhesion [TAS]
- cellular component movement [TAS]
- cortical actin cytoskeleton organization [IMP]
- negative regulation of receptor-mediated endocytosis [TAS]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of establishment of protein localization to plasma membrane [ISS]
- protein localization to cell surface [ISS]
- protein localization to endosome [IMP]
- regulation of Rac protein signal transduction [IDA]
- regulation of dendritic spine development [ISS]
- regulation of filopodium assembly [IDA]
- ruffle organization [IDA]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The arf6 GAP centaurin alpha-1 is a neuronal actin-binding protein which also functions via GAP-independent activity to regulate the actin cytoskeleton.
Centaurin alpha-1 is a high-affinity PtdIns(3,4,5)P3-binding protein enriched in brain. Sequence analysis indicates centaurin alpha-1 contains two pleckstrin homology domains, ankyrin repeats and an Arf GAP homology domain, placing it in the AZAP family of phosphoinositide-regulated Arf GAPs. Other members of this family are involved in actin cytoskeletal and focal adhesion organization. Recently, it was reported that centaurin alpha-1 expression ... [more]
Throughput
- Low Throughput
Additional Notes
- ADAP1 species not explicitly defined.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ARF6 ADAP1 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 2327793 |
Curated By
- BioGRID