A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

A Novel Epigenetic Silencing Pathway Involving the Highly Conserved 5'-3' Exoribonuclease Dhp1/Rat1/Xrn2 in Schizosaccharomyces pombe.

Tucker JF, Ohle C, Schermann G, Bendrin K, Zhang W, Fischer T, Zhang K

Epigenetic gene silencing plays a critical role in regulating gene expression and contributes to organismal development and cell fate acquisition in eukaryotes. In fission yeast, Schizosaccharomyces pombe, heterochromatin-associated gene silencing is known to be mediated by RNA processing pathways including RNA interference (RNAi) and a 3'-5' exoribonuclease complex, the exosome. Here, we report a new RNA-processing pathway that contributes to ... [more]

PLoS Genet. Feb. 01, 2016; 12(2);e1005873 [Pubmed: 26889830]

Throughput

Low Throughput

Ontology Terms

phenotype: viable (APO:0000113)

Curated By

BioGRID

Interaction Summary

DHP1

Gene Ontology Biological Process

Gene Ontology Molecular Function

5'-3' exoribonuclease activity [IDA]

Gene Ontology Cellular Component

RPB7