BAIT
CDC25C
CDC25, PPP1R60
cell division cycle 25C
GO Process (8)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
NF1
NFNS, VRNF, WSS
neurofibromin 1
GO Process (49)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- MAPK cascade [ISS]
- Ras protein signal transduction [ISS]
- Schwann cell development [ISS]
- actin cytoskeleton organization [ISS]
- adrenal gland development [ISS]
- artery morphogenesis [ISS]
- brain development [ISS]
- camera-type eye morphogenesis [ISS]
- cell communication [ISS]
- cerebral cortex development [ISS]
- cognition [IMP]
- collagen fibril organization [ISS]
- extracellular matrix organization [ISS]
- forebrain astrocyte development [ISS]
- forebrain morphogenesis [ISS]
- heart development [ISS]
- liver development [ISS]
- metanephros development [ISS]
- myelination in peripheral nervous system [ISS]
- negative regulation of MAP kinase activity [ISS]
- negative regulation of MAPK cascade [IMP, ISS]
- negative regulation of Ras protein signal transduction [IBA]
- negative regulation of cell migration [IMP]
- negative regulation of endothelial cell proliferation [IMP]
- negative regulation of fibroblast proliferation [ISS]
- negative regulation of neuroblast proliferation [ISS]
- negative regulation of oligodendrocyte differentiation [ISS]
- negative regulation of protein kinase activity [ISS]
- negative regulation of transcription factor import into nucleus [ISS]
- osteoblast differentiation [ISS]
- peripheral nervous system development [ISS]
- phosphatidylinositol 3-kinase signaling [ISS]
- pigmentation [ISS]
- positive regulation of Ras GTPase activity [IDA, IMP, ISS]
- positive regulation of adenylate cyclase activity [ISS]
- positive regulation of apoptotic process [ISS]
- positive regulation of neuron apoptotic process [ISS]
- regulation of Ras GTPase activity [IMP]
- regulation of angiogenesis [IMP]
- regulation of blood vessel endothelial cell migration [IMP]
- regulation of bone resorption [ISS]
- regulation of cell-matrix adhesion [ISS]
- regulation of glial cell differentiation [ISS]
- response to hypoxia [ISS]
- smooth muscle tissue development [ISS]
- spinal cord development [ISS]
- sympathetic nervous system development [ISS]
- visual learning [ISS]
- wound healing [ISS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Cellular organelles provide opportunities to relate biological mechanisms to disease. Here we use affinity proteomics, genetics and cell biology to interrogate cilia: poorly understood organelles, where defects cause genetic diseases. Two hundred and seventeen tagged human ciliary proteins create a final landscape of 1,319 proteins, 4,905 interactions and 52 complexes. Reverse tagging, repetition of purifications and statistical analyses, produce a ... [more]
Nat Commun May. 13, 2016; 7(0);11491 [Pubmed: 27173435]
Throughput
- High Throughput
Curated By
- BioGRID