BAIT
NRXN1
Hs.22998, PTHSL2, SCZD17
neurexin 1
GO Process (38)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- N-methyl-D-aspartate receptor clustering [ISS]
- adult behavior [IMP]
- angiogenesis [ISS]
- axon guidance [TAS]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- cerebellar granule cell differentiation [ISS]
- establishment of protein localization [ISS]
- extracellular matrix organization [TAS]
- gamma-aminobutyric acid receptor clustering [ISS]
- gephyrin clustering [ISS]
- guanylate kinase-associated protein clustering [ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- learning [IMP]
- negative regulation of filopodium assembly [ISS]
- neuroligin clustering [ISS]
- neuromuscular process controlling balance [IMP, ISS]
- neuron cell-cell adhesion [ISS, TAS]
- neuronal signal transduction [TAS]
- neurotransmitter secretion [ISS]
- positive regulation of establishment of protein localization to plasma membrane [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of synapse assembly [ISS]
- positive regulation of synapse maturation [ISS]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- postsynaptic density protein 95 clustering [ISS]
- postsynaptic membrane assembly [ISS]
- presynaptic membrane assembly [ISS]
- protein complex assembly involved in synapse maturation [ISS]
- protein localization to synapse [ISS]
- receptor localization to synapse [ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- social behavior [IMP]
- synapse assembly [ISS]
- synaptic transmission [ISS]
- synaptic vesicle clustering [ISS]
- vocal learning [IMP]
- vocalization behavior [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TULP1
LCA15, RP14, TUBL1, RP3-340B19.1
tubby like protein 1
GO Process (7)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Cellular organelles provide opportunities to relate biological mechanisms to disease. Here we use affinity proteomics, genetics and cell biology to interrogate cilia: poorly understood organelles, where defects cause genetic diseases. Two hundred and seventeen tagged human ciliary proteins create a final landscape of 1,319 proteins, 4,905 interactions and 52 complexes. Reverse tagging, repetition of purifications and statistical analyses, produce a ... [more]
Nat Commun May. 13, 2016; 7(0);11491 [Pubmed: 27173435]
Throughput
- High Throughput
Curated By
- BioGRID