BAIT
DNAAF1
CILD13, LRRC50, ODA7
dynein, axonemal, assembly factor 1
GO Process (14)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
- axonemal dynein complex assembly [IMP]
- cilium morphogenesis [IMP]
- cilium movement [IMP]
- determination of digestive tract left/right asymmetry [IMP]
- determination of liver left/right asymmetry [IMP]
- determination of pancreatic left/right asymmetry [IMP]
- epithelial cilium movement involved in determination of left/right asymmetry [IC]
- heart looping [IMP]
- inner dynein arm assembly [IMP]
- left/right pattern formation [IMP]
- lung development [IMP]
- motile cilium assembly [IMP]
- outer dynein arm assembly [IMP]
- regulation of cilium beat frequency [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
STOM
BND7, EPB7, EPB72, RP11-342H3.1
stomatin
GO Process (1)
GO Function (0)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Cellular organelles provide opportunities to relate biological mechanisms to disease. Here we use affinity proteomics, genetics and cell biology to interrogate cilia: poorly understood organelles, where defects cause genetic diseases. Two hundred and seventeen tagged human ciliary proteins create a final landscape of 1,319 proteins, 4,905 interactions and 52 complexes. Reverse tagging, repetition of purifications and statistical analyses, produce a ... [more]
Nat Commun May. 13, 2016; 7(0);11491 [Pubmed: 27173435]
Throughput
- High Throughput
Curated By
- BioGRID