BAIT
POL1
polA, swi7, SPAC3H5.06c
DNA polymerase alpha catalytic subunit
GO Process (7)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
RAD50
SPAP4C9.01c, SPAC1556.01c
DNA repair protein Rad50
GO Process (10)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- DNA duplex unwinding [TAS]
- double-strand break repair via homologous recombination [IGI]
- double-strand break repair via nonhomologous end joining [IMP]
- gene conversion at mating-type locus, DNA repair synthesis [IMP]
- homologous recombination-dependent replication fork processing [IMP]
- intra-S DNA damage checkpoint [IMP]
- meiotic DNA double-strand break formation [IMP]
- mitotic DNA damage checkpoint [IMP]
- reciprocal meiotic recombination [IMP]
- telomere maintenance [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Role of swi7H4 mutant allele of DNA polymerase α in the DNA damage checkpoint response.
Besides being a mediator of initiation of DNA replication, DNA polymerase α plays a key role in chromosome maintenance. Swi7H4, a novel temperature sensitive mutant of DNA polymerase α was shown to be defective in transcriptional silencing at the mating type centromere and telomere loci. It is also required for the establishment of chromatin state that can recruit the components ... [more]
PLoS ONE Mar. 31, 2015; 10(3);e0124063 [Pubmed: 25822347]
Throughput
- Low Throughput
Ontology Terms
- phenotype: viability (APO:0000111)
Curated By
- BioGRID