BAIT

LEM2

heh1, SPAC18G6.10
LEM domain protein Heh1/Lem2
Schizosaccharomyces pombe (972h)
PREY

DSH1

SPBC582.04c, SPBC582.04c
RNAi protein, Dsh1
GO Process (0)
GO Function (0)
GO Component (2)

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Control of heterochromatin localization and silencing by the nuclear membrane protein Lem2.

Barrales RR, Forn M, Georgescu PR, Sarkadi Z, Braun S

Transcriptionally silent chromatin localizes to the nuclear periphery, which provides a special microenvironment for gene repression. A variety of nuclear membrane proteins interact with repressed chromatin, yet the functional role of these interactions remains poorly understood. Here, we show that, in Schizosaccharomyces pombe, the nuclear membrane protein Lem2 associates with chromatin and mediates silencing and heterochromatin localization. Unexpectedly, we found ... [more]

Genes Dev. Jan. 15, 2016; 30(2);133-48 [Pubmed: 26744419]

Throughput

  • Low Throughput

Ontology Terms

  • silencing (APO:0000046)

Additional Notes

  • we found synthetic silencing defects in the dsh1/lem2 double mutant

Curated By

  • BioGRID