BRCT domain protein Brc1
GO Process (2)
GO Function (1)
GO Component (6)
Schizosaccharomyces pombe (972h)


Ku domain protein Pku70
GO Process (1)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


Ku stabilizes replication forks in the absence of Brc1.

Sanchez A, Russell P

DNA replication errors are a major source of genome instability in all organisms. In the fission yeast Schizosaccharomyces pombe, the DNA damage response protein Brc1 binds phospho-histone H2A (γH2A)-marked chromatin during S-phase, but how Brc1 protects genome integrity remains unclear. Here we report that the non-homologous end-joining (NHEJ) protein Ku becomes critical for survival of replication stress in brc1∆ cells. ... [more]

PLoS ONE May. 13, 2015; 10(5);e0126598 [Pubmed: 25965521]


  • Low Throughput

Ontology Terms

  • phenotype: viability (APO:0000111)
  • phenotype: resistance to chemicals (APO:0000087)
  • phenotype: uv resistance (APO:0000085)

Additional Notes

  • cis-phenotypic enhancing

Curated By

  • BioGRID