BAIT

BRC1

SPBC582.05c
BRCT domain protein Brc1
GO Process (2)
GO Function (1)
GO Component (6)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)
PREY

SWI3

SPBC30D10.04
replication fork protection complex subunit Swi3
GO Process (4)
GO Function (2)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Ku stabilizes replication forks in the absence of Brc1.

Sanchez A, Russell P

DNA replication errors are a major source of genome instability in all organisms. In the fission yeast Schizosaccharomyces pombe, the DNA damage response protein Brc1 binds phospho-histone H2A (γH2A)-marked chromatin during S-phase, but how Brc1 protects genome integrity remains unclear. Here we report that the non-homologous end-joining (NHEJ) protein Ku becomes critical for survival of replication stress in brc1∆ cells. ... [more]

PLoS ONE May. 13, 2015; 10(5);e0126598 [Pubmed: 25965521]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: viability (APO:0000111)

Additional Notes

  • cis-phenotypic enhancing
  • double mutants show increased sensitivity to DNA damaging agents

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
BRC1 SWI3
Synthetic Growth Defect
Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Low-PomBase
-

Curated By

  • BioGRID