Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair.

Tomida J, Itaya A, Shigechi T, Unno J, Uchida E, Ikura M, Masuda Y, Matsuda S, Adachi J, Kobayashi M, Meetei AR, Maehara Y, Yamamoto K, Kamiya K, Matsuura A, Matsuda T, Ikura T, Ishiai M, Takata M

When DNA replication is stalled at sites of DNA damage, a cascade of responses is activated in the cell to halt cell cycle progression and promote DNA repair. A pathway initiated by the kinase Ataxia teleangiectasia and Rad3 related (ATR) and its partner ATR interacting protein (ATRIP) plays an important role in this response. The Fanconi anemia (FA) pathway is ... [more]

Nucleic Acids Res. Aug. 01, 2013; 41(14);6930-41 [Pubmed: 23723247]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

ATRIP

Gene Ontology Biological Process

Gene Ontology Molecular Function

K63-linked polyubiquitin binding [IDA]protein binding [IPI]

Gene Ontology Cellular Component

C17ORF70