BAIT

MCM4

SPCC24B10.01, cdc21, SPCC16A11.17
MCM complex subunit Mcm4/Cdc21
Schizosaccharomyces pombe (972h)
PREY

RAD3

SPBC216.05
ATR checkpoint kinase Rad3
GO Process (3)
GO Function (2)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Characterization of a Novel MMS-Sensitive Allele of Schizosaccharomyces pombe mcm4.

Ranatunga NS, Forsburg SL

The minichromosome maintenance (MCM) complex is the conserved helicase motor of the eukaryotic replication fork. Mutations in the Mcm4 subunit are associated with replication stress and double strand breaks in multiple systems. In this work we characterize a new temperature sensitive allele of Schizosaccharomyces pombe mcm4(+) Uniquely amongst known mcm4 alleles, this mutation causes sensitivity to the alkylation damaging agent ... [more]

G3 (Bethesda) Jul. 29, 2016; 0(0); [Pubmed: 27473316]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: viability (APO:0000111)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
MCM4 RAD3
Phenotypic Enhancement
Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
298371

Curated By

  • BioGRID