BAIT
MCM4
SPCC24B10.01, cdc21, SPCC16A11.17
MCM complex subunit Mcm4/Cdc21
GO Process (2)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
SWI1
SPBC216.06c
replication fork protection complex subunit Swi1
GO Process (6)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Characterization of a Novel MMS-Sensitive Allele of Schizosaccharomyces pombe mcm4.
The minichromosome maintenance (MCM) complex is the conserved helicase motor of the eukaryotic replication fork. Mutations in the Mcm4 subunit are associated with replication stress and double strand breaks in multiple systems. In this work we characterize a new temperature sensitive allele of Schizosaccharomyces pombe mcm4(+) Uniquely amongst known mcm4 alleles, this mutation causes sensitivity to the alkylation damaging agent ... [more]
G3 (Bethesda) Jul. 29, 2016; 0(0); [Pubmed: 27473316]
Throughput
- Low Throughput
Ontology Terms
- phenotype: viability (APO:0000111)
Curated By
- BioGRID