Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


Characterization of a Novel MMS-Sensitive Allele of Schizosaccharomyces pombe mcm4.

Ranatunga NS, Forsburg SL

The minichromosome maintenance (MCM) complex is the conserved helicase motor of the eukaryotic replication fork. Mutations in the Mcm4 subunit are associated with replication stress and double strand breaks in multiple systems. In this work we characterize a new temperature sensitive allele of Schizosaccharomyces pombe mcm4(+) Uniquely amongst known mcm4 alleles, this mutation causes sensitivity to the alkylation damaging agent ... [more]

G3 (Bethesda) Jul. 29, 2016; 0(0); [Pubmed: 27473316]


  • Low Throughput

Ontology Terms

  • phenotype: viability (APO:0000111)

Curated By

  • BioGRID