CLR4
Gene Ontology Biological Process
- attachment of mitotic spindle microtubules to kinetochore [IMP]
- cellular protein localization [IMP]
- chromatin silencing at centromere [IMP]
- chromatin silencing at rDNA [IMP]
- chromatin silencing at silent mating-type cassette [IMP]
- chromatin silencing at telomere [TAS]
- chromatin silencing by small RNA [IMP]
- donor selection [IMP]
- heterochromatin assembly [NAS]
- heterochromatin maintenance involved in chromatin silencing at centromere outer repeat region [IGI]
- histone H3-K9 methylation [IDA]
- meiotic telomere clustering [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- peptidyl-lysine methylation [IDA]
- regulation of Ran protein signal transduction [TAS]
- regulation of production of siRNA involved in RNA interference [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CCQ1
Gene Ontology Biological Process
- cellular protein localization [IMP]
- chromatin silencing at telomere [IMP]
- meiotic chromosome segregation [IMP]
- meiotic telomere clustering [IMP]
- negative regulation of DNA recombination at telomere [IMP]
- positive regulation of telomere maintenance [IMP]
- positive regulation of telomere maintenance via telomerase [IGI]
- telomere capping [IGI]
- telomere maintenance [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The proper connection between shelterin components is required for telomeric heterochromatin assembly.
Telomeric regions contain prominent sites of heterochromatin, which is associated with unique histone modification profiles such as the methylation of histone H3 at Lys9 (H3K9me). In fission yeast, the conserved telomeric shelterin complex recruits the histone H3K9 methyltransferase complex CLRC to establish subtelomeric heterochromatin. Although many shelterin mutations affect subtelomeric heterochromatin assembly, the mechanism remains elusive due to the diverse ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CLR4 CCQ1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
| CLR4 CCQ1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CLR4 CCQ1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -2.3676 | BioGRID | 791236 | |
| CCQ1 CLR4 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -2.3676 | BioGRID | 787407 |
Curated By
- BioGRID