MCS6
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CDC2
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [IMP]
- cellular response to nitrogen starvation [IMP]
- negative regulation of G0 to G1 transition [IMP]
- negative regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation [IMP]
- negative regulation of induction of conjugation with cellular fusion [EXP]
- positive regulation of G1/S transition of mitotic cell cycle [IMP]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of mitotic cytokinesis [IMP]
- positive regulation of septation initiation signaling [IMP]
- regulation of cell size [NAS]
- regulation of meiotic cell cycle [IMP]
- response to intra-S DNA damage checkpoint signaling [IMP]
- traversing start control point of mitotic cell cycle [NAS]
Gene Ontology Molecular Function
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Fission yeast Cdk7 controls gene expression through both its CAK and C-terminal domain kinase activities.
Cyclin-dependent kinase (Cdk) activation and RNA polymerase II transcription are linked by the Cdk7 kinase, which phosphorylates Cdks as a trimeric Cdk-activating kinase (CAK) complex, and serine 5 within the polymerase II (Pol II) C-terminal domain (CTD) as transcription factor TFIIH-bound CAK. However, the physiological importance of integrating these processes is not understood. Besides the Cdk7 ortholog Mcs6, fission yeast ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDC2 MCS6 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 247353 | |
| MCS6 CDC2 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 247264 | |
| CDC2 MCS6 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 247267 |
Curated By
- BioGRID