BAIT
AGAP2
AGAP-2, Centg1, PIKE, cnt-g1, mKIAA0167
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
GO Process (15)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- actin cytoskeleton organization [ISO]
- endosomal transport [ISO]
- mammary gland alveolus development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of protein catabolic process [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of JAK-STAT cascade [IMP]
- positive regulation of mammary gland epithelial cell proliferation [IGI, IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of phosphatidylinositol 3-kinase activity [ISO]
Gene Ontology Molecular Function
Mus musculus
PREY
ANK3
2900054D09Rik, AI314020, Ank-3, AnkG, Ankyrin-3, Ankyrin-G
ankyrin 3, epithelial
GO Process (23)
GO Function (7)
GO Component (24)
Gene Ontology Biological Process
- Golgi to plasma membrane protein transport [ISO]
- axon guidance [IMP]
- axonogenesis [IMP]
- establishment of protein localization [ISO]
- maintenance of protein location in plasma membrane [ISO]
- membrane assembly [ISO]
- mitotic cytokinesis [ISO]
- neuronal action potential [IMP]
- plasma membrane organization [ISO]
- positive regulation of action potential [TAS]
- positive regulation of cation channel activity [ISO]
- positive regulation of cell communication by electrical coupling [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of homotypic cell-cell adhesion [ISO]
- positive regulation of membrane depolarization during cardiac muscle cell action potential [ISO]
- positive regulation of membrane potential [ISO]
- positive regulation of protein targeting to membrane [ISO]
- positive regulation of sodium ion transmembrane transporter activity [ISO]
- positive regulation of sodium ion transport [ISO]
- protein localization to plasma membrane [IDA, IMP, ISO]
- protein targeting to plasma membrane [IMP, ISO]
- regulation of potassium ion transport [ISO]
- synapse organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [ISO]
- Z disc [ISO]
- axon [IDA]
- axon initial segment [IDA, ISO]
- basal plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- cell [IMP]
- cell surface [ISO]
- dendrite [ISO]
- intercalated disc [IDA, ISO]
- intracellular [IMP]
- lateral plasma membrane [ISO]
- membrane [IDA]
- neuromuscular junction [ISO]
- neuron projection [ISO]
- node of Ranvier [IDA, ISO]
- paranode region of axon [IDA]
- plasma membrane [ISO]
- postsynaptic membrane [ISO]
- sarcolemma [ISO]
- sarcoplasmic reticulum [ISO]
- spectrin-associated cytoskeleton [ISO]
- synapse [IDA]
- tight junction [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.
GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs) play essential roles in regulating the activity of small GTPases. Several GAPs and GEFs have been shown to be present at the postsynaptic density (PSD) within excitatory glutamatergic neurons and regulate the activity of glutamate receptors. However, it is not known how synaptic GAP and GEF proteins are organized within the PSD ... [more]
Sci Rep Jul. 13, 2017; 7(1);5272 [Pubmed: 28706196]
Throughput
- High Throughput
Additional Notes
- Postsynaptic density (PSD) interactions
Curated By
- BioGRID