BAIT
AGAP2
AGAP-2, Centg1, PIKE, cnt-g1, mKIAA0167
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
GO Process (15)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- actin cytoskeleton organization [ISO]
- endosomal transport [ISO]
- mammary gland alveolus development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of protein catabolic process [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of JAK-STAT cascade [IMP]
- positive regulation of mammary gland epithelial cell proliferation [IGI, IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of phosphatidylinositol 3-kinase activity [ISO]
Gene Ontology Molecular Function
Mus musculus
PREY
CAMK2B
RP23-340E18.5
calcium/calmodulin-dependent protein kinase II, beta
GO Process (17)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- activation of meiosis involved in egg activation [IMP]
- calcium ion transport [IMP]
- cell projection morphogenesis [ISO]
- inhibitory G-protein coupled receptor phosphorylation [IDA]
- long-term synaptic potentiation [ISO]
- neuromuscular process controlling balance [IMP]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of apoptotic signaling pathway [IDA]
- positive regulation of dendritic spine morphogenesis [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of phospholipase A2 activity [ISO]
- positive regulation of synapse maturation [ISO]
- protein autophosphorylation [IMP, ISO]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of synaptic transmission, cholinergic [IMP]
- response to cadmium ion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.
GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs) play essential roles in regulating the activity of small GTPases. Several GAPs and GEFs have been shown to be present at the postsynaptic density (PSD) within excitatory glutamatergic neurons and regulate the activity of glutamate receptors. However, it is not known how synaptic GAP and GEF proteins are organized within the PSD ... [more]
Sci Rep Jul. 13, 2017; 7(1);5272 [Pubmed: 28706196]
Throughput
- High Throughput
Additional Notes
- Non-postsynaptic density (PSD) interactions
- Postsynaptic density (PSD) interactions
Curated By
- BioGRID