BAIT
AGAP2
AGAP-2, Centg1, PIKE, cnt-g1, mKIAA0167
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
GO Process (15)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- actin cytoskeleton organization [ISO]
- endosomal transport [ISO]
- mammary gland alveolus development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of protein catabolic process [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of JAK-STAT cascade [IMP]
- positive regulation of mammary gland epithelial cell proliferation [IGI, IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of phosphatidylinositol 3-kinase activity [ISO]
Gene Ontology Molecular Function
Mus musculus
PREY
DLG3
Dlgh3, SAP102, mKIAA1232, RP23-142M12.1
discs, large homolog 3 (Drosophila)
GO Process (9)
GO Function (10)
GO Component (13)
Gene Ontology Biological Process
- embryo development [IBA]
- establishment of planar polarity [IMP]
- establishment or maintenance of epithelial cell apical/basal polarity [IMP]
- negative regulation of phosphatase activity [ISO]
- nervous system development [IBA]
- nucleotide phosphorylation [IBA]
- receptor clustering [IBA]
- receptor localization to synapse [IBA]
- synaptic transmission [IBA]
Gene Ontology Molecular Function- PDZ domain binding [ISO]
- guanylate kinase activity [IBA]
- ionotropic glutamate receptor binding [IBA, ISO]
- kinase binding [ISO]
- phosphatase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein phosphatase binding [ISO]
- ubiquitin protein ligase binding [IPI]
- PDZ domain binding [ISO]
- guanylate kinase activity [IBA]
- ionotropic glutamate receptor binding [IBA, ISO]
- kinase binding [ISO]
- phosphatase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein phosphatase binding [ISO]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA]
- basolateral plasma membrane [IBA]
- cell-cell junction [IDA]
- cytoplasm [IDA]
- dendritic shaft [ISO]
- extracellular space [ISO]
- growth cone [ISO]
- neuronal cell body [ISO]
- plasma membrane [IDA]
- postsynaptic density [IBA, ISO]
- postsynaptic membrane [IBA]
- synapse [ISO]
- tight junction [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.
GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs) play essential roles in regulating the activity of small GTPases. Several GAPs and GEFs have been shown to be present at the postsynaptic density (PSD) within excitatory glutamatergic neurons and regulate the activity of glutamate receptors. However, it is not known how synaptic GAP and GEF proteins are organized within the PSD ... [more]
Sci Rep Jul. 13, 2017; 7(1);5272 [Pubmed: 28706196]
Throughput
- High Throughput
Additional Notes
- Postsynaptic density (PSD) interactions
Curated By
- BioGRID