BAIT
AGAP2
AGAP-2, Centg1, PIKE, cnt-g1, mKIAA0167
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
GO Process (15)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- actin cytoskeleton organization [ISO]
- endosomal transport [ISO]
- mammary gland alveolus development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of protein catabolic process [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of JAK-STAT cascade [IMP]
- positive regulation of mammary gland epithelial cell proliferation [IGI, IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of phosphatidylinositol 3-kinase activity [ISO]
Gene Ontology Molecular Function
Mus musculus
PREY
NLGN1
6330415N05Rik, BB179718, NL1, Nlg1, mKIAA1070
neuroligin 1
GO Process (38)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- N-methyl-D-aspartate receptor clustering [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IDA, IMP, ISO]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [IDA, ISO]
- cytoskeletal matrix organization at active zone [IMP, ISO]
- establishment of protein localization [IMP]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- nervous system development [IDA]
- neurexin clustering [IDA]
- neuron cell-cell adhesion [IDA, ISO]
- positive regulation of dendritic spine development [ISO]
- positive regulation of excitatory postsynaptic membrane potential [IDA, ISO]
- positive regulation of filopodium assembly [ISO]
- positive regulation of intracellular signal transduction [ISO]
- positive regulation of ruffle assembly [ISO]
- positive regulation of synapse assembly [IDA, ISO]
- positive regulation of synaptic transmission, GABAergic [ISO]
- positive regulation of synaptic transmission, glutamatergic [ISO]
- positive regulation of synaptic vesicle endocytosis [IMP, ISO]
- positive regulation of synaptic vesicle exocytosis [IMP, ISO]
- postsynaptic density protein 95 clustering [IDA, ISO]
- postsynaptic membrane assembly [IDA]
- presynaptic membrane assembly [IDA, ISO]
- protein heterotetramerization [ISO]
- protein homooligomerization [IDA]
- protein localization to synapse [IDA]
- protein targeting [ISO]
- receptor localization to synapse [IDA]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IDA, ISO]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISO]
- regulation of inhibitory postsynaptic membrane potential [IMP]
- regulation of neuron differentiation [IDA]
- regulation of respiratory gaseous exchange by neurological system process [IGI]
- regulation of synaptic transmission [IGI]
- synapse assembly [IDA, ISO]
- synapse organization [IGI, ISO]
- synaptic vesicle clustering [IDA, ISO]
- synaptic vesicle targeting [IMP]
- terminal button organization [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.
GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs) play essential roles in regulating the activity of small GTPases. Several GAPs and GEFs have been shown to be present at the postsynaptic density (PSD) within excitatory glutamatergic neurons and regulate the activity of glutamate receptors. However, it is not known how synaptic GAP and GEF proteins are organized within the PSD ... [more]
Sci Rep Jul. 13, 2017; 7(1);5272 [Pubmed: 28706196]
Throughput
- High Throughput
Additional Notes
- Postsynaptic density (PSD) interactions
Curated By
- BioGRID