BAIT
AGAP2
AGAP-2, Centg1, PIKE, cnt-g1, mKIAA0167
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
GO Process (15)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- actin cytoskeleton organization [ISO]
- endosomal transport [ISO]
- mammary gland alveolus development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of protein catabolic process [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of JAK-STAT cascade [IMP]
- positive regulation of mammary gland epithelial cell proliferation [IGI, IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of phosphatidylinositol 3-kinase activity [ISO]
Gene Ontology Molecular Function
Mus musculus
PREY
SHANK1
SH3/ankyrin domain gene 1
GO Process (18)
GO Function (10)
GO Component (11)
Gene Ontology Biological Process
- adult behavior [ISO]
- associative learning [IMP]
- dendritic spine morphogenesis [IMP]
- determination of affect [ISO]
- habituation [IMP]
- long-term memory [IMP]
- negative regulation of actin filament bundle assembly [IDA]
- neuromuscular process controlling balance [IMP]
- olfactory behavior [IMP]
- positive regulation of dendritic spine development [ISO]
- positive regulation of excitatory postsynaptic membrane potential [IMP]
- protein complex assembly [ISO]
- protein localization to synapse [IMP]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IMP]
- righting reflex [IMP]
- social behavior [IMP, ISO]
- synapse maturation [ISO]
- vocalization behavior [IMP, ISO]
Gene Ontology Molecular Function- GKAP/Homer scaffold activity [IMP, ISO]
- SH3 domain binding [ISO]
- ankyrin repeat binding [ISO]
- identical protein binding [ISO]
- ionotropic glutamate receptor binding [IPI, ISO]
- protein C-terminus binding [ISO]
- protein complex binding [ISO]
- receptor signaling complex scaffold activity [ISO]
- scaffold protein binding [ISO]
- somatostatin receptor binding [ISO]
- GKAP/Homer scaffold activity [IMP, ISO]
- SH3 domain binding [ISO]
- ankyrin repeat binding [ISO]
- identical protein binding [ISO]
- ionotropic glutamate receptor binding [IPI, ISO]
- protein C-terminus binding [ISO]
- protein complex binding [ISO]
- receptor signaling complex scaffold activity [ISO]
- scaffold protein binding [ISO]
- somatostatin receptor binding [ISO]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [ISO]
- dendrite [IDA]
- dendritic spine [IDA, ISO]
- excitatory synapse [IDA]
- ionotropic glutamate receptor complex [IDA]
- membrane [ISO]
- neuron projection [IDA]
- neuronal postsynaptic density [IDA]
- plasma membrane [IDA]
- postsynaptic membrane [IDA, ISO]
- synapse [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.
GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs) play essential roles in regulating the activity of small GTPases. Several GAPs and GEFs have been shown to be present at the postsynaptic density (PSD) within excitatory glutamatergic neurons and regulate the activity of glutamate receptors. However, it is not known how synaptic GAP and GEF proteins are organized within the PSD ... [more]
Sci Rep Jul. 13, 2017; 7(1);5272 [Pubmed: 28706196]
Throughput
- High Throughput
Additional Notes
- Postsynaptic density (PSD) interactions
Curated By
- BioGRID