SYNGAP1
Gene Ontology Biological Process
- Ras protein signal transduction [IDA]
- dendrite development [IMP]
- negative regulation of Ras protein signal transduction [IBA, ISO]
- negative regulation of axonogenesis [IDA]
- negative regulation of neuron apoptotic process [IMP]
- pattern specification process [IMP]
- positive regulation of Rab GTPase activity [IDA]
- positive regulation of Ras GTPase activity [IBA, ISO]
- receptor clustering [IMP]
- regulation of MAPK cascade [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI, IMP]
- regulation of synapse structure or activity [IMP]
- regulation of synaptic plasticity [ISO]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GLUL
Gene Ontology Biological Process
- ammonia assimilation cycle [ISO]
- cell proliferation [ISO]
- cellular response to starvation [IEP]
- glutamate metabolic process [ISO]
- glutamine biosynthetic process [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of insulin secretion [ISO]
- positive regulation of synaptic transmission, glutamatergic [ISO]
- protein homooligomerization [ISO]
- response to glucose [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon terminus [ISO]
- cell body [IDA]
- cell projection [ISO]
- cytoplasm [IDA, ISO]
- extracellular vesicular exosome [ISO]
- glial cell projection [IDA]
- intracellular membrane-bounded organelle [ISO]
- mitochondrion [IDA]
- myelin sheath [IDA]
- neuron projection [ISO]
- nucleus [ISO]
- perikaryon [ISO]
- protein complex [ISO]
- rough endoplasmic reticulum [ISO]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.
GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs) play essential roles in regulating the activity of small GTPases. Several GAPs and GEFs have been shown to be present at the postsynaptic density (PSD) within excitatory glutamatergic neurons and regulate the activity of glutamate receptors. However, it is not known how synaptic GAP and GEF proteins are organized within the PSD ... [more]
Throughput
- High Throughput
Additional Notes
- Postsynaptic density (PSD) interactions
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SYNGAP1 GLUL | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| SYNGAP1 GLUL | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2343641 | |
| SYNGAP1 GLUL | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 0.2422 | BioGRID | 3500032 |
Curated By
- BioGRID