BAIT
SYNGAP1
Gm1963, Syngap
synaptic Ras GTPase activating protein 1 homolog (rat)
GO Process (14)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- Ras protein signal transduction [IDA]
- dendrite development [IMP]
- negative regulation of Ras protein signal transduction [IBA, ISO]
- negative regulation of axonogenesis [IDA]
- negative regulation of neuron apoptotic process [IMP]
- pattern specification process [IMP]
- positive regulation of Rab GTPase activity [IDA]
- positive regulation of Ras GTPase activity [IBA, ISO]
- receptor clustering [IMP]
- regulation of MAPK cascade [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI, IMP]
- regulation of synapse structure or activity [IMP]
- regulation of synaptic plasticity [ISO]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
IQGAP1
AA682088, D7Ertd237e, D7Ertd257e, mKIAA0051
IQ motif containing GTPase activating protein 1
GO Process (12)
GO Function (9)
GO Component (21)
Gene Ontology Biological Process
- cellular response to calcium ion [ISO]
- cellular response to epidermal growth factor stimulus [IMP, ISO]
- cellular response to fibroblast growth factor stimulus [IMP]
- cellular response to platelet-derived growth factor stimulus [IMP]
- epidermal growth factor receptor signaling pathway [IMP, ISO]
- fibroblast growth factor receptor signaling pathway [IMP]
- negative regulation of dephosphorylation [IGI]
- neuron projection extension [ISO]
- platelet-derived growth factor receptor signaling pathway [IMP]
- positive regulation of protein kinase activity [IMP, ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- regulation of cytokine production [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [ISO]
- axon [ISO]
- cell junction [ISO]
- cell leading edge [IGI]
- cell-cell junction [IDA]
- cytoplasm [IDA, ISO]
- cytoplasmic ribonucleoprotein granule [ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [ISO]
- focal adhesion [ISO]
- growth cone [ISO]
- lateral plasma membrane [IDA]
- membrane [IDA]
- microtubule [ISO]
- microtubule cytoskeleton [ISO]
- midbody [ISO]
- neuron projection [IGI, ISO]
- nucleoplasm [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- ribonucleoprotein complex [IDA, IGI]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.
GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs) play essential roles in regulating the activity of small GTPases. Several GAPs and GEFs have been shown to be present at the postsynaptic density (PSD) within excitatory glutamatergic neurons and regulate the activity of glutamate receptors. However, it is not known how synaptic GAP and GEF proteins are organized within the PSD ... [more]
Sci Rep Jul. 13, 2017; 7(1);5272 [Pubmed: 28706196]
Throughput
- High Throughput
Additional Notes
- Postsynaptic density (PSD) interactions
Curated By
- BioGRID