BAIT
SYNGAP1
Gm1963, Syngap
synaptic Ras GTPase activating protein 1 homolog (rat)
GO Process (14)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- Ras protein signal transduction [IDA]
- dendrite development [IMP]
- negative regulation of Ras protein signal transduction [IBA, ISO]
- negative regulation of axonogenesis [IDA]
- negative regulation of neuron apoptotic process [IMP]
- pattern specification process [IMP]
- positive regulation of Rab GTPase activity [IDA]
- positive regulation of Ras GTPase activity [IBA, ISO]
- receptor clustering [IMP]
- regulation of MAPK cascade [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI, IMP]
- regulation of synapse structure or activity [IMP]
- regulation of synaptic plasticity [ISO]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NTRK3
AW125844, Ntrk3_tv3, TrkC
neurotrophic tyrosine kinase, receptor, type 3
GO Process (20)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- activation of MAPK activity [ISO]
- activation of Ras GTPase activity [ISO]
- activation of protein kinase B activity [ISO]
- lens fiber cell differentiation [IGI]
- mechanoreceptor differentiation [IMP]
- negative regulation of astrocyte differentiation [ISO]
- negative regulation of cell death [ISO]
- negative regulation of protein phosphorylation [ISO]
- neuron fate specification [ISO]
- neuron migration [ISO]
- neurotrophin signaling pathway [ISO]
- positive regulation of actin cytoskeleton reorganization [ISO]
- positive regulation of axon extension involved in regeneration [IGI]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of positive chemotaxis [ISO]
- protein autophosphorylation [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.
GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs) play essential roles in regulating the activity of small GTPases. Several GAPs and GEFs have been shown to be present at the postsynaptic density (PSD) within excitatory glutamatergic neurons and regulate the activity of glutamate receptors. However, it is not known how synaptic GAP and GEF proteins are organized within the PSD ... [more]
Sci Rep Jul. 13, 2017; 7(1);5272 [Pubmed: 28706196]
Throughput
- High Throughput
Additional Notes
- Postsynaptic density (PSD) interactions
Curated By
- BioGRID