BAIT
KALRN
2210407G14Rik, AV235988, DUET, E530005C20Rik, Gm539, Hapip, TRAD, RP23-363L9.1
kalirin, RhoGEF kinase
GO Process (4)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HOMER1
PSD-Zip45, SYN47, Ves-1, homer-1, vesl-1
homer homolog 1 (Drosophila)
GO Process (11)
GO Function (9)
GO Component (14)
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [ISO, TAS]
- behavioral response to cocaine [IMP]
- chemical homeostasis within a tissue [IMP]
- positive regulation of calcium ion transport [IMP]
- protein localization to synapse [ISO]
- regulation of calcium ion import [IMP]
- regulation of cation channel activity [IMP]
- regulation of store-operated calcium entry [IMP]
- response to calcium ion [ISO]
- skeletal muscle contraction [IMP]
- skeletal muscle fiber development [IMP]
Gene Ontology Molecular Function- G-protein coupled glutamate receptor binding [IBA, ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- protein binding [IPI]
- protein complex scaffold [ISO]
- protein heterodimerization activity [ISO]
- receptor binding [ISO]
- scaffold protein binding [ISO]
- type 5 metabotropic glutamate receptor binding [ISO]
- G-protein coupled glutamate receptor binding [IBA, ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- protein binding [IPI]
- protein complex scaffold [ISO]
- protein heterodimerization activity [ISO]
- receptor binding [ISO]
- scaffold protein binding [ISO]
- type 5 metabotropic glutamate receptor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.
GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs) play essential roles in regulating the activity of small GTPases. Several GAPs and GEFs have been shown to be present at the postsynaptic density (PSD) within excitatory glutamatergic neurons and regulate the activity of glutamate receptors. However, it is not known how synaptic GAP and GEF proteins are organized within the PSD ... [more]
Sci Rep Jul. 13, 2017; 7(1);5272 [Pubmed: 28706196]
Throughput
- High Throughput
Additional Notes
- Postsynaptic density (PSD) interactions
Curated By
- BioGRID