BAIT
KALRN
2210407G14Rik, AV235988, DUET, E530005C20Rik, Gm539, Hapip, TRAD, RP23-363L9.1
kalirin, RhoGEF kinase
GO Process (4)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PDE4D
9630011N22Rik, Dpde3, RP24-383A20.1
phosphodiesterase 4D, cAMP specific
GO Process (16)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- aging [IMP]
- cAMP catabolic process [IDA, IMP]
- cellular response to epinephrine stimulus [IMP]
- cellular response to lipopolysaccharide [IMP]
- leukocyte migration [IMP]
- multicellular organism growth [IMP]
- negative regulation of heart contraction [IMP]
- negative regulation of peptidyl-serine phosphorylation [IMP]
- negative regulation of relaxation of cardiac muscle [IMP]
- neutrophil chemotaxis [IMP]
- regulation of cardiac muscle cell contraction [IMP]
- regulation of cell communication by electrical coupling involved in cardiac conduction [IC]
- regulation of heart rate [IMP]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IMP]
- regulation of ryanodine-sensitive calcium-release channel activity [IMP]
- smooth muscle contraction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.
GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs) play essential roles in regulating the activity of small GTPases. Several GAPs and GEFs have been shown to be present at the postsynaptic density (PSD) within excitatory glutamatergic neurons and regulate the activity of glutamate receptors. However, it is not known how synaptic GAP and GEF proteins are organized within the PSD ... [more]
Sci Rep Jul. 13, 2017; 7(1);5272 [Pubmed: 28706196]
Throughput
- High Throughput
Additional Notes
- Postsynaptic density (PSD) interactions
Curated By
- BioGRID