BAIT
AGAP2
AGAP-2, Centg1, PIKE, cnt-g1, mKIAA0167
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
GO Process (15)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- actin cytoskeleton organization [ISO]
- endosomal transport [ISO]
- mammary gland alveolus development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of protein catabolic process [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of JAK-STAT cascade [IMP]
- positive regulation of mammary gland epithelial cell proliferation [IGI, IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of phosphatidylinositol 3-kinase activity [ISO]
Gene Ontology Molecular Function
Mus musculus
PREY
CDK5
AW048668, Crk6
cyclin-dependent kinase 5
GO Process (69)
GO Function (13)
GO Component (17)
Gene Ontology Biological Process
- Schwann cell development [IMP]
- apoptotic process [IDA]
- associative learning [IMP]
- axonogenesis [IMP]
- behavioral response to cocaine [IMP]
- calcium ion import [IMP]
- cell migration [IDA, IMP]
- cell-matrix adhesion [IDA]
- central nervous system neuron development [IMP]
- cerebellar cortex development [IMP]
- cerebellar cortex formation [IMP]
- cerebellum development [IMP]
- cerebral cortex development [IMP]
- corpus callosum development [IMP]
- cortical actin cytoskeleton organization [ISO]
- dendrite morphogenesis [IMP]
- exocytosis [ISO]
- forebrain development [IMP]
- hippocampus development [IMP]
- intracellular protein transport [IMP]
- layer formation in cerebral cortex [IMP]
- motor neuron axon guidance [IMP]
- negative regulation of axon extension [IGI]
- negative regulation of cell cycle [IMP]
- negative regulation of neuron death [ISO]
- negative regulation of protein export from nucleus [IMP]
- negative regulation of protein ubiquitination [IMP]
- negative regulation of proteolysis [ISO]
- negative regulation of synaptic plasticity [IMP]
- negative regulation of transcription, DNA-templated [ISO]
- neuron apoptotic process [IMP, ISO]
- neuron differentiation [IMP, ISA, ISO]
- neuron migration [IMP]
- neuron projection development [ISO]
- neuron projection morphogenesis [ISO]
- nucleocytoplasmic transport [ISO]
- oligodendrocyte differentiation [ISO]
- peptidyl-serine phosphorylation [IDA, IMP, ISO]
- peptidyl-threonine phosphorylation [IDA]
- phosphorylation [ISO]
- positive regulation of calcium ion-dependent exocytosis [IDA]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein binding [IMP]
- positive regulation of protein kinase activity [IMP]
- positive regulation of protein targeting to membrane [IMP]
- positive regulation of receptor activity [IDA]
- protein autophosphorylation [ISO]
- protein localization to synapse [IMP]
- protein phosphorylation [IDA, IGI, IMP, ISO]
- receptor catabolic process [IMP]
- receptor clustering [IMP]
- regulated secretory pathway [ISO]
- regulation of cell cycle [ISO]
- regulation of cell migration [IMP]
- regulation of dendritic spine morphogenesis [IMP]
- regulation of excitatory postsynaptic membrane potential [IMP]
- regulation of postsynaptic membrane potential [IMP]
- regulation of synaptic plasticity [ISO]
- response to cocaine [IMP]
- response to wounding [ISO]
- sensory perception of pain [IMP]
- serine phosphorylation of STAT3 protein [IDA]
- skeletal muscle tissue development [IDA]
- synapse assembly [IMP]
- synaptic transmission, dopaminergic [IMP]
- synaptic transmission, glutamatergic [IMP]
- synaptic vesicle endocytosis [ISO]
- telencephalon development [IMP]
- visual learning [IMP]
Gene Ontology Molecular Function- ErbB-2 class receptor binding [IDA]
- ErbB-3 class receptor binding [IDA]
- acetylcholine receptor activator activity [IDA]
- cyclin-dependent protein serine/threonine kinase activity [ISO]
- cytoskeletal protein binding [ISO]
- ephrin receptor binding [ISO]
- kinase activity [ISO]
- p53 binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA, IMP, ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- tau-protein kinase activity [ISO]
- ErbB-2 class receptor binding [IDA]
- ErbB-3 class receptor binding [IDA]
- acetylcholine receptor activator activity [IDA]
- cyclin-dependent protein serine/threonine kinase activity [ISO]
- cytoskeletal protein binding [ISO]
- ephrin receptor binding [ISO]
- kinase activity [ISO]
- p53 binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA, IMP, ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- tau-protein kinase activity [ISO]
Gene Ontology Cellular Component
- axon [IDA, ISO]
- cell [IMP]
- cyclin-dependent protein kinase 5 holoenzyme complex [ISO]
- cytoplasm [IDA, ISO]
- cytoskeleton [ISO]
- cytosol [IDA]
- dendrite [ISO]
- filopodium [IDA]
- growth cone [ISO]
- intracellular [IMP]
- lamellipodium [IDA]
- membrane [ISO]
- neuromuscular junction [ISO]
- neuronal cell body [ISO]
- nucleolus [IDA]
- nucleus [IDA, ISO]
- postsynaptic density [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.
GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs) play essential roles in regulating the activity of small GTPases. Several GAPs and GEFs have been shown to be present at the postsynaptic density (PSD) within excitatory glutamatergic neurons and regulate the activity of glutamate receptors. However, it is not known how synaptic GAP and GEF proteins are organized within the PSD ... [more]
Sci Rep Jul. 13, 2017; 7(1);5272 [Pubmed: 28706196]
Throughput
- High Throughput
Additional Notes
- Non-postsynaptic density (PSD) interactions
Curated By
- BioGRID