BAIT
AGAP2
AGAP-2, Centg1, PIKE, cnt-g1, mKIAA0167
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
GO Process (15)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- actin cytoskeleton organization [ISO]
- endosomal transport [ISO]
- mammary gland alveolus development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of protein catabolic process [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of JAK-STAT cascade [IMP]
- positive regulation of mammary gland epithelial cell proliferation [IGI, IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of phosphatidylinositol 3-kinase activity [ISO]
Gene Ontology Molecular Function
Mus musculus
PREY
PCNA
RP23-33N15.1
proliferating cell nuclear antigen
GO Process (8)
GO Function (10)
GO Component (12)
Gene Ontology Biological Process
- base-excision repair, gap-filling [IDA]
- leading strand elongation [IBA]
- mismatch repair [IBA, ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of deoxyribonuclease activity [ISO]
- regulation of catalytic activity [IBA]
- response to lipid [ISO]
- translesion synthesis [IBA, ISO]
Gene Ontology Molecular Function- DNA polymerase binding [ISO]
- DNA polymerase processivity factor activity [IBA]
- MutLalpha complex binding [ISO]
- dinucleotide insertion or deletion binding [ISO]
- estrogen receptor binding [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- purine-specific mismatch base pair DNA N-glycosylase activity [ISO]
- receptor tyrosine kinase binding [ISO]
- transcription factor binding [IPI]
- DNA polymerase binding [ISO]
- DNA polymerase processivity factor activity [IBA]
- MutLalpha complex binding [ISO]
- dinucleotide insertion or deletion binding [ISO]
- estrogen receptor binding [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- purine-specific mismatch base pair DNA N-glycosylase activity [ISO]
- receptor tyrosine kinase binding [ISO]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.
GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs) play essential roles in regulating the activity of small GTPases. Several GAPs and GEFs have been shown to be present at the postsynaptic density (PSD) within excitatory glutamatergic neurons and regulate the activity of glutamate receptors. However, it is not known how synaptic GAP and GEF proteins are organized within the PSD ... [more]
Sci Rep Jul. 13, 2017; 7(1);5272 [Pubmed: 28706196]
Throughput
- High Throughput
Additional Notes
- Non-postsynaptic density (PSD) interactions
Curated By
- BioGRID