ESPN
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BAIAP2
Gene Ontology Biological Process
- actin crosslink formation [ISO, ISS]
- actin filament bundle assembly [ISO, ISS]
- dendrite development [ISO]
- positive regulation of dendritic spine morphogenesis [IMP]
- regulation of actin cytoskeleton organization [ISO, ISS]
- regulation of cell shape [ISO, ISS]
- regulation of synaptic plasticity [ISO]
- response to bacterium [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Novel espin actin-bundling proteins are localized to Purkinje cell dendritic spines and bind the Src homology 3 adapter protein insulin receptor substrate p53.
We identified a group of actin-binding-bundling proteins that are expressed in cerebellar Purkinje cells (PCs) but are not detected in other neurons of the CNS. These proteins are novel isoforms of the actin-bundling protein espin that arise through the use of a unique site for transcriptional initiation and differential splicing. Light and electron microscopic localization studies demonstrated that these espin ... [more]
Throughput
- Low Throughput
Additional Notes
- ESPN isoform Q63618-3
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BAIAP2 ESPN | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 2333522 | |
| ESPN BAIAP2 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 2333523 |
Curated By
- BioGRID