GRIK2
Gene Ontology Biological Process
- behavioral fear response [ISO]
- cellular calcium ion homeostasis [ISO]
- intracellular protein transport [ISO]
- ion transmembrane transport [IBA, ISO]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of synaptic transmission, glutamatergic [IDA, ISO]
- neuron apoptotic process [IMP]
- neuronal action potential [ISO]
- positive regulation of neuron apoptotic process [IMP]
- positive regulation of synaptic transmission [ISO]
- receptor clustering [IDA]
- regulation of JNK cascade [IMP]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of inhibitory postsynaptic membrane potential [ISO]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of membrane potential [ISO]
- regulation of short-term neuronal synaptic plasticity [ISO]
- regulation of synaptic transmission [ISO]
- signal transduction [IDA]
- synaptic transmission [IMP, ISO]
- synaptic transmission, glutamatergic [ISO]
Gene Ontology Molecular Function- PDZ domain binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate receptor activity [IDA]
- identical protein binding [IDA]
- ionotropic glutamate receptor activity [ISO, TAS]
- kainate selective glutamate receptor activity [IDA, ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase binding [IPI]
- PDZ domain binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate receptor activity [IDA]
- identical protein binding [IDA]
- ionotropic glutamate receptor activity [ISO, TAS]
- kainate selective glutamate receptor activity [IDA, ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
- axon [IDA]
- cell [ISO]
- dendrite [IDA]
- dendrite cytoplasm [IDA]
- integral component of plasma membrane [IDA]
- intracellular [ISO]
- ionotropic glutamate receptor complex [IDA]
- kainate selective glutamate receptor complex [IBA, ISO]
- membrane [ISO]
- neuronal cell body [ISO]
- perikaryon [IDA]
- postsynaptic density [ISO]
- postsynaptic membrane [IBA, ISO]
- presynaptic membrane [IBA, ISO]
- synapse [IDA, ISO]
- terminal bouton [IDA]
DLG4
Gene Ontology Biological Process
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IMP]
- dendritic spine morphogenesis [IMP, ISO]
- establishment of protein localization [ISO, ISS]
- locomotory exploration behavior [ISO, ISS]
- negative regulation of receptor internalization [IDA]
- neuromuscular process controlling balance [ISO, ISS]
- neuronal ion channel clustering [TAS]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of excitatory postsynaptic membrane potential [IDA]
- positive regulation of synaptic transmission [IDA]
- protein complex assembly [ISO, ISS]
- protein localization to synapse [IMP, ISO]
- receptor localization to synapse [IMP]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IDA]
- regulation of grooming behavior [ISO, ISS]
- regulation of long-term neuronal synaptic plasticity [ISO, ISS]
- social behavior [ISO, ISS]
- synaptic vesicle maturation [ISO, ISS]
- vocalization behavior [ISO, ISS]
Gene Ontology Molecular Function- D1 dopamine receptor binding [IPI]
- P2Y1 nucleotide receptor binding [IPI]
- PDZ domain binding [IPI]
- acetylcholine receptor binding [IDA]
- beta-1 adrenergic receptor binding [IPI]
- glutamate receptor binding [IPI]
- ionotropic glutamate receptor binding [IPI, ISO]
- protein C-terminus binding [IPI, ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- receptor binding [IPI]
- scaffold protein binding [ISO, ISS]
- D1 dopamine receptor binding [IPI]
- P2Y1 nucleotide receptor binding [IPI]
- PDZ domain binding [IPI]
- acetylcholine receptor binding [IDA]
- beta-1 adrenergic receptor binding [IPI]
- glutamate receptor binding [IPI]
- ionotropic glutamate receptor binding [IPI, ISO]
- protein C-terminus binding [IPI, ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- receptor binding [IPI]
- scaffold protein binding [ISO, ISS]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [ISO, ISS]
- cell junction [ISO, ISS]
- cerebellar mossy fiber [ISO]
- cortical cytoskeleton [ISO]
- cytoplasm [ISO, ISS]
- dendrite [ISO]
- dendrite cytoplasm [IDA]
- dendritic spine [ISS]
- endoplasmic reticulum [ISO, ISS]
- excitatory synapse [IDA, ISO]
- extrinsic component of cytoplasmic side of plasma membrane [ISO, ISS]
- ionotropic glutamate receptor complex [ISO, ISS]
- juxtaparanode region of axon [IDA, ISO]
- membrane [IDA, ISO]
- neuron projection terminus [ISO, ISS]
- neuron spine [ISO, ISS]
- neuronal postsynaptic density [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA, ISO]
- synapse [IDA, ISO]
- synaptic membrane [ISO]
- synaptic vesicle [ISO, ISS]
- voltage-gated potassium channel complex [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Neuroprotection against transient focal cerebral ischemia and oxygen-glucose deprivation by interference with GluR6-PSD95 protein interaction.
Previous studies have shown that KA receptor subunit GluR6 mediated c-Jun N-terminal protein kinase (JNK) signaling is involved in global ischemia injury. Our present study indicates that focal ischemic brain insult on rat middle cerebral artery occlusion (MACo) model enhances the assembly of the GluR6-PSD95-MLK3 module and facilitates the phosphorylation of JNK. Most importantly, a peptide containing the TAT protein ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
DLG4 GRIK2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID