GRIK2
Gene Ontology Biological Process
- behavioral fear response [ISO]
- cellular calcium ion homeostasis [ISO]
- intracellular protein transport [ISO]
- ion transmembrane transport [IBA, ISO]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of synaptic transmission, glutamatergic [IDA, ISO]
- neuron apoptotic process [IMP]
- neuronal action potential [ISO]
- positive regulation of neuron apoptotic process [IMP]
- positive regulation of synaptic transmission [ISO]
- receptor clustering [IDA]
- regulation of JNK cascade [IMP]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of inhibitory postsynaptic membrane potential [ISO]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of membrane potential [ISO]
- regulation of short-term neuronal synaptic plasticity [ISO]
- regulation of synaptic transmission [ISO]
- signal transduction [IDA]
- synaptic transmission [IMP, ISO]
- synaptic transmission, glutamatergic [ISO]
Gene Ontology Molecular Function- PDZ domain binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate receptor activity [IDA]
- identical protein binding [IDA]
- ionotropic glutamate receptor activity [ISO, TAS]
- kainate selective glutamate receptor activity [IDA, ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase binding [IPI]
- PDZ domain binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate receptor activity [IDA]
- identical protein binding [IDA]
- ionotropic glutamate receptor activity [ISO, TAS]
- kainate selective glutamate receptor activity [IDA, ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
- axon [IDA]
- cell [ISO]
- dendrite [IDA]
- dendrite cytoplasm [IDA]
- integral component of plasma membrane [IDA]
- intracellular [ISO]
- ionotropic glutamate receptor complex [IDA]
- kainate selective glutamate receptor complex [IBA, ISO]
- membrane [ISO]
- neuronal cell body [ISO]
- perikaryon [IDA]
- postsynaptic density [ISO]
- postsynaptic membrane [IBA, ISO]
- presynaptic membrane [IBA, ISO]
- synapse [IDA, ISO]
- terminal bouton [IDA]
MAP3K11
Gene Ontology Biological Process
- JNK cascade [IDA]
- activation of JNKK activity [IDA]
- activation of JUN kinase activity [ISO]
- activation of MAPK activity [ISO]
- cell death [IMP]
- cell proliferation [ISO]
- microtubule-based process [ISO]
- positive regulation of JNK cascade [ISO]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of apoptotic process [IMP]
- positive regulation of neuron apoptotic process [IMP]
- protein autophosphorylation [IDA, ISO]
- protein phosphorylation [IDA, ISO]
Gene Ontology Molecular Function- ATP binding [IDA]
- JUN kinase kinase kinase activity [IDA]
- MAP kinase kinase kinase activity [IDA]
- Rac GTPase binding [IPI]
- identical protein binding [ISO]
- mitogen-activated protein kinase kinase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- ATP binding [IDA]
- JUN kinase kinase kinase activity [IDA]
- MAP kinase kinase kinase activity [IDA]
- Rac GTPase binding [IPI]
- identical protein binding [ISO]
- mitogen-activated protein kinase kinase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Neuroprotection against transient focal cerebral ischemia and oxygen-glucose deprivation by interference with GluR6-PSD95 protein interaction.
Previous studies have shown that KA receptor subunit GluR6 mediated c-Jun N-terminal protein kinase (JNK) signaling is involved in global ischemia injury. Our present study indicates that focal ischemic brain insult on rat middle cerebral artery occlusion (MACo) model enhances the assembly of the GluR6-PSD95-MLK3 module and facilitates the phosphorylation of JNK. Most importantly, a peptide containing the TAT protein ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MAP3K11 GRIK2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID