BAIT
ESO1
SPBC16A3.11
sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein
GO Process (7)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- DNA biosynthetic process [ISO]
- DNA repair [ISO]
- establishment of mitotic sister chromatid cohesion [IMP]
- peptidyl-lysine N6-acetylation [IMP]
- positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric [IMP]
- regulation of maintenance of mitotic sister chromatid cohesion [TAS]
- translesion synthesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
PSY2
SPBC216.01c, SPBC713.13c, SPBC216.01c
protein phosphatase PP4 complex subunit Psy2 (predicted)
GO Process (1)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
A second Wpl1 anti-cohesion pathway requires dephosphorylation of fission yeast kleisin Rad21 by PP4.
Cohesin mediates sister chromatid cohesion which is essential for chromosome segregation and repair. Sister chromatid cohesion requires an acetyl-transferase (Eso1 in fission yeast) counteracting Wpl1, promoting cohesin release from DNA We report here that Wpl1 anti-cohesion function includes an additional mechanism. A genetic screen uncovered that Protein Phosphatase 4 (PP4) mutants allowed cell survival in the complete absence of Eso1. ... [more]
EMBO J. May. 15, 2017; 36(10);1364-1378 [Pubmed: 28438891]
Throughput
- Low Throughput
Ontology Terms
- heat sensitivity (APO:0000147)
Curated By
- BioGRID