DLG4
Gene Ontology Biological Process
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IBA, ISO]
- dendritic spine morphogenesis [IDA, ISO]
- establishment of protein localization [ISO]
- locomotory behavior [NAS]
- locomotory exploration behavior [IMP]
- negative regulation of receptor internalization [ISO]
- neuromuscular process controlling balance [IMP]
- nucleotide phosphorylation [IBA]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of excitatory postsynaptic membrane potential [ISO]
- positive regulation of synaptic transmission [ISO]
- protein complex assembly [ISO]
- protein localization to synapse [IDA, ISO]
- receptor localization to synapse [IBA, ISO]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISO]
- regulation of grooming behavior [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI]
- regulation of neuronal synaptic plasticity [NAS]
- response to cocaine [NAS]
- signal transduction [IBA]
- social behavior [IMP]
- synaptic vesicle maturation [IDA, IGI]
- vocalization behavior [IMP]
Gene Ontology Molecular Function- D1 dopamine receptor binding [ISO]
- P2Y1 nucleotide receptor binding [ISO]
- PDZ domain binding [ISO]
- acetylcholine receptor binding [ISO]
- beta-1 adrenergic receptor binding [ISO]
- glutamate receptor binding [ISO]
- guanylate kinase activity [IBA]
- ionotropic glutamate receptor binding [IPI, ISO]
- kinase binding [ISO]
- neurexin family protein binding [NAS]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- scaffold protein binding [IPI]
- structural molecule activity [NAS]
- D1 dopamine receptor binding [ISO]
- P2Y1 nucleotide receptor binding [ISO]
- PDZ domain binding [ISO]
- acetylcholine receptor binding [ISO]
- beta-1 adrenergic receptor binding [ISO]
- glutamate receptor binding [ISO]
- guanylate kinase activity [IBA]
- ionotropic glutamate receptor binding [IPI, ISO]
- kinase binding [ISO]
- neurexin family protein binding [NAS]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- scaffold protein binding [IPI]
- structural molecule activity [NAS]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA]
- cell junction [IDA]
- cerebellar mossy fiber [IDA]
- cortical cytoskeleton [ISO]
- cytoplasm [IDA]
- cytosol [ISO]
- dendrite [IDA]
- dendrite cytoplasm [ISO]
- endoplasmic reticulum [IDA]
- excitatory synapse [IDA, ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IDA]
- ionotropic glutamate receptor complex [IDA]
- juxtaparanode region of axon [IDA, ISO]
- membrane [IDA, ISO]
- neuron projection terminus [IDA]
- neuron spine [IDA]
- neuronal postsynaptic density [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA, ISO]
- synapse [IDA, ISO]
- synaptic membrane [IDA]
- synaptic vesicle [IDA]
- voltage-gated potassium channel complex [ISO]
CDK5
Gene Ontology Biological Process
- Schwann cell development [IMP]
- apoptotic process [IDA]
- associative learning [IMP]
- axonogenesis [IMP]
- behavioral response to cocaine [IMP]
- calcium ion import [IMP]
- cell migration [IDA, IMP]
- cell-matrix adhesion [IDA]
- central nervous system neuron development [IMP]
- cerebellar cortex development [IMP]
- cerebellar cortex formation [IMP]
- cerebellum development [IMP]
- cerebral cortex development [IMP]
- corpus callosum development [IMP]
- cortical actin cytoskeleton organization [ISO]
- dendrite morphogenesis [IMP]
- exocytosis [ISO]
- forebrain development [IMP]
- hippocampus development [IMP]
- intracellular protein transport [IMP]
- layer formation in cerebral cortex [IMP]
- motor neuron axon guidance [IMP]
- negative regulation of axon extension [IGI]
- negative regulation of cell cycle [IMP]
- negative regulation of neuron death [ISO]
- negative regulation of protein export from nucleus [IMP]
- negative regulation of protein ubiquitination [IMP]
- negative regulation of proteolysis [ISO]
- negative regulation of synaptic plasticity [IMP]
- negative regulation of transcription, DNA-templated [ISO]
- neuron apoptotic process [IMP, ISO]
- neuron differentiation [IMP, ISA, ISO]
- neuron migration [IMP]
- neuron projection development [ISO]
- neuron projection morphogenesis [ISO]
- nucleocytoplasmic transport [ISO]
- oligodendrocyte differentiation [ISO]
- peptidyl-serine phosphorylation [IDA, IMP, ISO]
- peptidyl-threonine phosphorylation [IDA]
- phosphorylation [ISO]
- positive regulation of calcium ion-dependent exocytosis [IDA]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein binding [IMP]
- positive regulation of protein kinase activity [IMP]
- positive regulation of protein targeting to membrane [IMP]
- positive regulation of receptor activity [IDA]
- protein autophosphorylation [ISO]
- protein localization to synapse [IMP]
- protein phosphorylation [IDA, IGI, IMP, ISO]
- receptor catabolic process [IMP]
- receptor clustering [IMP]
- regulated secretory pathway [ISO]
- regulation of cell cycle [ISO]
- regulation of cell migration [IMP]
- regulation of dendritic spine morphogenesis [IMP]
- regulation of excitatory postsynaptic membrane potential [IMP]
- regulation of postsynaptic membrane potential [IMP]
- regulation of synaptic plasticity [ISO]
- response to cocaine [IMP]
- response to wounding [ISO]
- sensory perception of pain [IMP]
- serine phosphorylation of STAT3 protein [IDA]
- skeletal muscle tissue development [IDA]
- synapse assembly [IMP]
- synaptic transmission, dopaminergic [IMP]
- synaptic transmission, glutamatergic [IMP]
- synaptic vesicle endocytosis [ISO]
- telencephalon development [IMP]
- visual learning [IMP]
Gene Ontology Molecular Function- ErbB-2 class receptor binding [IDA]
- ErbB-3 class receptor binding [IDA]
- acetylcholine receptor activator activity [IDA]
- cyclin-dependent protein serine/threonine kinase activity [ISO]
- cytoskeletal protein binding [ISO]
- ephrin receptor binding [ISO]
- kinase activity [ISO]
- p53 binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA, IMP, ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- tau-protein kinase activity [ISO]
- ErbB-2 class receptor binding [IDA]
- ErbB-3 class receptor binding [IDA]
- acetylcholine receptor activator activity [IDA]
- cyclin-dependent protein serine/threonine kinase activity [ISO]
- cytoskeletal protein binding [ISO]
- ephrin receptor binding [ISO]
- kinase activity [ISO]
- p53 binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA, IMP, ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- tau-protein kinase activity [ISO]
Gene Ontology Cellular Component
- axon [IDA, ISO]
- cell [IMP]
- cyclin-dependent protein kinase 5 holoenzyme complex [ISO]
- cytoplasm [IDA, ISO]
- cytoskeleton [ISO]
- cytosol [IDA]
- dendrite [ISO]
- filopodium [IDA]
- growth cone [ISO]
- intracellular [IMP]
- lamellipodium [IDA]
- membrane [ISO]
- neuromuscular junction [ISO]
- neuronal cell body [ISO]
- nucleolus [IDA]
- nucleus [IDA, ISO]
- postsynaptic density [ISO]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Throughput
- High Throughput|Low Throughput
Additional Notes
- Developmental stage: Adult
- Developmental stage: p14
- Postsynaptic density (PSD) scaffold protein Dlg4 was immunoprecipitated and its interactors were identified via mass spec.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
DLG4 CDK5 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID