DLGAP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PPP3CB
Gene Ontology Biological Process
- T cell differentiation [IMP]
- T cell homeostasis [IMP]
- calcineurin-NFAT signaling cascade [ISO]
- calcium ion-dependent exocytosis [IDA]
- cellular response to drug [ISO]
- dephosphorylation [IDA]
- heart development [IMP]
- locomotion involved in locomotory behavior [IMP]
- lymphangiogenesis [IGI]
- negative regulation of T cell mediated cytotoxicity [IMP]
- positive regulation of NFAT protein import into nucleus [ISO]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein dephosphorylation [IMP, ISO]
- protein phosphorylation [IMP]
- regulation of gene expression [IMP]
- regulation of insulin secretion [ISO]
- response to cytokine [IMP]
- response to stress [IMP]
Gene Ontology Molecular Function- calcium ion binding [ISO]
- calcium-dependent protein serine/threonine phosphatase activity [ISO]
- calmodulin binding [ISO]
- calmodulin-dependent protein phosphatase activity [IMP]
- drug binding [ISO]
- enzyme binding [ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- protein phosphatase 2B binding [ISO]
- protein serine/threonine phosphatase activity [IDA]
- calcium ion binding [ISO]
- calcium-dependent protein serine/threonine phosphatase activity [ISO]
- calmodulin binding [ISO]
- calmodulin-dependent protein phosphatase activity [IMP]
- drug binding [ISO]
- enzyme binding [ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- protein phosphatase 2B binding [ISO]
- protein serine/threonine phosphatase activity [IDA]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Throughput
- High Throughput
Additional Notes
- Developmental stage: Adult
- Postsynaptic density (PSD) scaffold protein Dlgap1 was immunoprecipitated and its interactors were identified via mass spec.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
DLGAP1 PPP3CB | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID