SHANK3
Gene Ontology Biological Process
- MAPK cascade [IGI]
- N-methyl-D-aspartate receptor clustering [IMP]
- adult behavior [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IMP]
- brain morphogenesis [IMP]
- dendritic spine morphogenesis [IMP]
- embryonic epithelial tube formation [IGI]
- guanylate kinase-associated protein clustering [IMP]
- learning [IMP, ISO]
- locomotory exploration behavior [IMP]
- memory [IMP]
- negative regulation of actin filament bundle assembly [IDA]
- negative regulation of cell volume [IMP]
- neuromuscular process controlling balance [IMP]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IMP]
- positive regulation of dendritic spine development [IMP]
- positive regulation of excitatory postsynaptic membrane potential [IMP]
- positive regulation of glutamate receptor signaling pathway [IMP, ISO]
- positive regulation of long-term neuronal synaptic plasticity [IMP]
- positive regulation of synapse structural plasticity [IMP]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- postsynaptic density assembly [IMP]
- protein oligomerization [ISO]
- regulation of behavioral fear response [IMP]
- regulation of dendritic spine morphogenesis [IMP]
- regulation of grooming behavior [IMP]
- regulation of long term synaptic depression [IMP]
- regulation of long-term synaptic potentiation [IMP]
- social behavior [IMP, ISO]
- striatal medium spiny neuron differentiation [IMP]
- synapse assembly [IMP]
- vocal learning [ISO]
- vocalization behavior [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PRKCE
Gene Ontology Biological Process
- TRAM-dependent toll-like receptor 4 signaling pathway [IMP]
- cellular response to ethanol [IGI]
- cellular response to hypoxia [IDA]
- cellular response to prostaglandin E stimulus [IDA]
- chemosensory behavior [TAS]
- intracellular signal transduction [ISO]
- lipopolysaccharide-mediated signaling pathway [IMP]
- locomotory exploration behavior [IGI]
- macrophage activation involved in immune response [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of mitochondrial calcium ion concentration [ISO]
- negative regulation of mitochondrial membrane potential [ISO]
- negative regulation of release of sequestered calcium ion into cytosol [ISO]
- peptidyl-serine phosphorylation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of MAPK cascade [IDA, IMP]
- positive regulation of actin filament polymerization [IDA]
- positive regulation of catalytic activity [ISO]
- positive regulation of cell-substrate adhesion [IGI, IMP]
- positive regulation of cellular glucuronidation [ISO]
- positive regulation of cytokinesis [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of fibroblast migration [IMP]
- positive regulation of insulin secretion [IMP]
- positive regulation of lipid catabolic process [IMP]
- positive regulation of mucus secretion [IMP]
- positive regulation of receptor activity [IDA]
- positive regulation of synaptic transmission, GABAergic [IMP]
- positive regulation of wound healing [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- regulation of lipid metabolic process [IMP]
- regulation of peptidyl-tyrosine phosphorylation [IMP]
- regulation of release of sequestered calcium ion into cytosol [IDA]
- release of sequestered calcium ion into cytosol [IMP]
- response to morphine [IMP]
Gene Ontology Molecular Function- 14-3-3 protein binding [IPI]
- SH3 domain binding [ISO]
- actin monomer binding [IDA]
- calcium-independent protein kinase C activity [IDA]
- enzyme activator activity [ISO]
- enzyme binding [ISO]
- ethanol binding [IDA]
- protein binding [IPI]
- protein kinase C activity [ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- receptor activator activity [IDA]
- receptor binding [ISO]
- 14-3-3 protein binding [IPI]
- SH3 domain binding [ISO]
- actin monomer binding [IDA]
- calcium-independent protein kinase C activity [IDA]
- enzyme activator activity [ISO]
- enzyme binding [ISO]
- ethanol binding [IDA]
- protein binding [IPI]
- protein kinase C activity [ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- receptor activator activity [IDA]
- receptor binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Throughput
- High Throughput
Additional Notes
- Developmental stage: Adult
- Developmental stage: p14
- Developmental stage: p7
- Postsynaptic density (PSD) scaffold protein Shank3 was immunoprecipitated and its interactors were identified via mass spec.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SHANK3 PRKCE | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID