WEE1
Gene Ontology Biological Process
- cytokinesis after mitosis checkpoint [IGI]
- mitotic DNA damage checkpoint [IMP]
- mitotic cell cycle checkpoint [IMP]
- negative regulation of G2/M transition of mitotic cell cycle [IMP]
- negative regulation of protein kinase activity by regulation of protein phosphorylation [IDA]
- peptidyl-serine autophosphorylation [IDA]
- peptidyl-tyrosine autophosphorylation [IDA]
- regulation of cell size [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAD3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Consequences of abnormal CDK activity in S phase.
Cyclin Dependent Kinases (CDKs) are important regulators of DNA replication. In this work we have investigated the consequences of increasing or decreasing the CDK activity in S phase. To this end we identified S-phase regulators of the fission yeast CDK, Cdc2, and used appropriate mutants to modulate Cdc2 activity. In fission yeast Mik1 has been thought to be the main ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: viability (APO:0000111)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| WEE1 RAD3 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | PomBase | - | |
| RAD3 WEE1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 798436 |
Curated By
- BioGRID