A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Genetic and structural analysis of the essential fission yeast RNA polymerase II CTD phosphatase Fcp1.

Schwer B, Ghosh A, Sanchez AM, Lima CD, Shuman S

Protein phosphatases regulate mRNA synthesis and processing by remodeling the carboxy-terminal domain (CTD) of RNA polymerase II (Pol2) to dynamically inscribe a Pol2 CTD code. Fission yeast Fcp1 (SpFcp1) is an essential 723-amino acid CTD phosphatase that preferentially hydrolyzes Ser2-PO4 of the YS(2)PTSPS repeat. The SpFcp1 catalytic domain (aa 140-580) is composed of a DxDxT acyl-phosphatase module (FCPH) and a ... [more]

RNA Jun. 01, 2015; 21(6);1135-46 [Pubmed: 25883047]

Throughput

Low Throughput

Ontology Terms

phenotype: viability (APO:0000111)

Curated By

BioGRID

Interaction Summary

FCP1

Gene Ontology Biological Process

Gene Ontology Molecular Function

CTD phosphatase activity [IDA]protein binding [IPI]

Gene Ontology Cellular Component

SSU72